Volume 28, Issue 1 (4-2026)
yafte 2026, 28(1): 77-87 |
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Tayebi R, Janbozorgi M, Alizade A, Taheri A. The effect of 8 weeks of high-intensity interval training combined with curcumin consumption on NF-KB and NFR2 factors in aged rat heart tissue. yafte 2026; 28 (1) :77-87
URL: http://yafte.lums.ac.ir/article-1-3883-en.html
URL: http://yafte.lums.ac.ir/article-1-3883-en.html
Department of Exercise Physiology, Faculty of Sport Sciences, Shahid Chamran University OF Ahvaz, Ahvaz, Iran
Abstract: (296 Views)
Background: With increasing age, chronic inflammation and metabolic disorders increase significantly, which can lead to cardiovascular diseases. This study investigated the effect of 8 weeks of high-intensity interval training with curcumin consumption on NF-KB and NRF2 factors in the heart tissue of aged rats.
Materials and Methods: In this study, 35 aged male Wistar rats with an average weight of 250-300 g were divided into five groups: healthy control group, aged control, aged + training, training + curcumin supplement, and training + curcumin supplement. To induce aging, rats were injected with D-galactose at a dose of 500 mg/kg for eight weeks. HIIT training consisted of a 10-minute warm-up, followed by three running stages at an intensity of % 80-90 Vmax for four minutes and rest for three minutes. Curcumin supplements were given to rats for eight weeks at a dose of 50 mg/kg. After the intervention period, heart tissue samples were extracted, and the gene expression levels of NF-KB and NRF2 factors were evaluated using Real-time-PCR. Data analysis was performed using one-way ANOVA and Tukey post hoc test.
Results: The results showed that senescence induction led to a significant increase in NF-KB and a significant decrease in NRF2 (P < 0/05). The combination of HIIT and curcumin reversed these effects, decreased NF-KB expression, and increased NRF2 expression (P < 0/05).
Conclusion: The results of this study showed that HIIT training and curcumin consumption reduce inflammation in the heart tissue of aged rats by inhibiting the NF-KB and NRF2 signaling pathways. Therefore, the combination of curcumin and HIIT training can be used as an effective strategy to reduce inflammation and enhance antioxidant defense in the heart tissue of older people.
Materials and Methods: In this study, 35 aged male Wistar rats with an average weight of 250-300 g were divided into five groups: healthy control group, aged control, aged + training, training + curcumin supplement, and training + curcumin supplement. To induce aging, rats were injected with D-galactose at a dose of 500 mg/kg for eight weeks. HIIT training consisted of a 10-minute warm-up, followed by three running stages at an intensity of % 80-90 Vmax for four minutes and rest for three minutes. Curcumin supplements were given to rats for eight weeks at a dose of 50 mg/kg. After the intervention period, heart tissue samples were extracted, and the gene expression levels of NF-KB and NRF2 factors were evaluated using Real-time-PCR. Data analysis was performed using one-way ANOVA and Tukey post hoc test.
Results: The results showed that senescence induction led to a significant increase in NF-KB and a significant decrease in NRF2 (P < 0/05). The combination of HIIT and curcumin reversed these effects, decreased NF-KB expression, and increased NRF2 expression (P < 0/05).
Conclusion: The results of this study showed that HIIT training and curcumin consumption reduce inflammation in the heart tissue of aged rats by inhibiting the NF-KB and NRF2 signaling pathways. Therefore, the combination of curcumin and HIIT training can be used as an effective strategy to reduce inflammation and enhance antioxidant defense in the heart tissue of older people.
Type of Study: Original Research |
Subject:
قلب و عروق
Received: 2025/11/30 | Accepted: 2026/02/28 | Published: 2026/04/30
Received: 2025/11/30 | Accepted: 2026/02/28 | Published: 2026/04/30
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