Volume 11, Number 1 (yafteh 2009)                   yafte 2009, 11(1): 43-48 | Back to browse issues page


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Khosravi A, Asadollahi E, Hommel P. Production of monoclonal antibody to MSP-2 and evaluation of different domains of the molecule. yafte. 2009; 11 (1) :43-48
URL: http://yafte.lums.ac.ir/article-1-852-en.html

Abstract:   (8045 Views)
Background: Plasmodiom falciparum MSP-2 is taken into accout as one of the candidates of vaccine agaist malaria and various studies indicated immunizing effect of different domains of the molecule. Monoclonal antibody against MSP-2 is a confident and definite method to confirm this Immunization. Materials and Methods: P. falciparum Parasite was Prepared in a Culture in CludingRPMI1640 and Schizontantingens extracted and injected into the mice. Then B Lyphocytes of immunized mice were extracted from their spleen and the fusion was Performed using NS-1 and monoclonal antibody to MSP-2 was Produced. Results: Anumber of monoclonal antibody to MSP-2 weres Produced which confirmed efficiency and Immunizing effects of various domains of MSP-2 molecule.
Full-Text [PDF 167 kb]   (1657 Downloads)    
Type of Study: Research |
Received: 2012/11/6 | Accepted: 2017/11/14

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