Volume 13, Issue 3 (12-2011)                   yafte 2011, 13(3): 82-96 | Back to browse issues page

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Shahsavar F, Mousavi T, Entezami K, Azargoon A R. Association of KIR-HLA interactions with diseases. yafte. 2011; 13 (3) :82-96
URL: http://yafte.lums.ac.ir/article-1-566-en.html
Tehran University of Medical Sciences,
Abstract:   (9578 Views)
The killer cell immunoglobulin-like receptors (KIR) are a recently discovered family of activating and inhibitory receptors which control natural killer (NK) cell function. KIR exist as a diverse family of receptors that have evolved rapidly by both gene duplication and recombination events. These findings were unexpected for a family of genes involved primarily in the innate immune response. Human leukocyte antigen (HLA) class I molecules serve as ligands for the KIR. Several disease association studies indicate a role for interactions between these loci in infectious diseases, autoimmune/inflammatory disorders, cancer and reproduction. Emerging functional data supports a mechanism based on a continuum of inhibition to activation through various compound KIR-HLA genotypes in diseases. This review summarizes the major features of these genes and discusses how they may be involved in both disease pathogenesis and its amelioration.
Full-Text [PDF 307 kb]   (2098 Downloads)    
Type of Study: Research |
Received: 2011/12/6

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