Volume 27, Issue 1 (12-2025)
yafte 2025, 27(1): 53-66 |
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Mohammadian M, Bahaoddini A, Namavar M. Investigation of the Effect of IC87201, a PSD95/nNOS Inhibitor, on Reducing Cardiac Complications After Stroke in Male Rats. yafte 2025; 27 (1) :53-66
URL: http://yafte.lums.ac.ir/article-1-3762-en.html
URL: http://yafte.lums.ac.ir/article-1-3762-en.html
Department of Biology, Faculty of Sciences, Shiraz University, Shiraz, Iran & Department of Biology, Faculty of Sciences, Shiraz University, Shiraz, Iran
Abstract: (226 Views)
Background: Abnormalities of electrocardiogram and cardiac arrhythmias after stroke are very common. This study investigated the effect of IC87201, a molecule affecting the NMDA receptor intracellular signaling pathway, on reducing QT interval prolongation, as the most common electrocardiogram change after cerebral ischemia, in male rats.
Materials and Methods: In this study, 15 male adult rats were randomly divided into three groups: MCAO, MCAO+DXM (dextromethorphan hydrobromide monohydrate, NMDA receptor antagonist), and MCAO+IC87201 (n=5 each). Two hours after ischemia, solvent, DXM, and IC87201 were injected intraperitoneally into these three groups, respectively. Pre-ischemia, four hours, and forty-eight hours post-ischemia neurological-behavioral scores were assessed using the neurological deficit score test. Statistical differences were measured using repeated measures analysis of variance (P<0.05).
Results: QT interval significantly prolonged after ischemia. Administration of IC87201 significantly reduced this interval, whereas DXM did not have such an effect. The LF/HF ratio, as an index of autonomic nervous system balance on cardiac performance, significantly increased forty-eight hours after ischemia. This imbalance improved forty-eight hours after the injection of both IC87201 and DXM.
Conclusion: The results of this study indicated that cerebral ischemia could lead to an increase in sympathetic activity, which in turn causes prolonged QT interval. The administration of IC87201 may be effective in improving this condition by reducing the QT interval. Therefore, IC87201 may potentially be considered a suitable option for reducing cardiac complications following stroke.
Materials and Methods: In this study, 15 male adult rats were randomly divided into three groups: MCAO, MCAO+DXM (dextromethorphan hydrobromide monohydrate, NMDA receptor antagonist), and MCAO+IC87201 (n=5 each). Two hours after ischemia, solvent, DXM, and IC87201 were injected intraperitoneally into these three groups, respectively. Pre-ischemia, four hours, and forty-eight hours post-ischemia neurological-behavioral scores were assessed using the neurological deficit score test. Statistical differences were measured using repeated measures analysis of variance (P<0.05).
Results: QT interval significantly prolonged after ischemia. Administration of IC87201 significantly reduced this interval, whereas DXM did not have such an effect. The LF/HF ratio, as an index of autonomic nervous system balance on cardiac performance, significantly increased forty-eight hours after ischemia. This imbalance improved forty-eight hours after the injection of both IC87201 and DXM.
Conclusion: The results of this study indicated that cerebral ischemia could lead to an increase in sympathetic activity, which in turn causes prolonged QT interval. The administration of IC87201 may be effective in improving this condition by reducing the QT interval. Therefore, IC87201 may potentially be considered a suitable option for reducing cardiac complications following stroke.
Type of Study: Research |
Subject:
قلب و عروق
Received: 2024/08/29 | Accepted: 2025/01/31 | Published: 2025/12/31
Received: 2024/08/29 | Accepted: 2025/01/31 | Published: 2025/12/31
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