Ahmad Kazemi, Nasser Behpour, Ahmad Hematfar,
Volume 22, Issue 2 (8-2020)
Abstract
Background: The incidence of heart disease increase with age. Green tea is an antioxidant which can prevent cellular aging. Therefore, the present study aims to investigate the effect of 12 weeks of green tea extract consumption on total antioxidant capacity (TAC), malondialdehyde (MDA) levels and superoxide dismutase, glutathione peroxidase and catalase activity of old rats' heart tissue in response to acute exhaustive exercise.
Materials and Methods: 32 male rats were randomly categorized into two groups of supplement and non-supplement each consisting of 16 rats. The supplement group received green tea extract for 12 weeks. At the end of the 12 weeks, each of these groups was further divided into two groups of rest and acute exhaustive exercise. The non-supplement with the rest group was called control group. The non-supplement with exercise group was called exercise group. Further, the supplement group with the rest was called supplement group and finally the last group was entitled supplement with exercise. After 12 weeks of taking green tea extract, one session of acute exhaustive exercise was held on the treadmill. Sandwich ELISA method was used to measure TAC and MDA content and superoxide dismutase, glutathione peroxidase and catalase activity
Results: The results showed that 12 weeks of green tea extract consumption increased TAC and decreased MDA levels. Furthermore, increased superoxide dismutase, glutathione peroxidase and catalase activity in response to a bout acute exhaustive exercise.
Conclusion: According to the results of this study, 12 weeks of green tea extract consumption can increase TAC levels and increase the activity of antioxidant enzymes at rest and after acute exhaustive exercise.
Abdollah Bagheri, Ahmad Hematfar, Mehdi Roozbahani, Naser Behpour,
Volume 22, Issue 4 (1-2021)
Abstract
Background: The aim of the present study was to investigate the effect of exercise pre-conditioning with intense intermittent exercise on MDA, SOD and GPx enzymes of myocardial infarction following acute myocardial infarction in male rats.
Materials and Methods: Based on this goal, 20 8-week-old male Wistar rats (mean weight 224.41 ± 5.1 g) were divided into 4 groups: control, training, stroke and stroke-training. The training groups performed two weeks of intense intermittent training in four sections. The first part of three days of training, two sessions per day and each session consisting of 4 intense two-minute intervals at a speed of 35 to 40 meters per minute . In the second part, two training days, two training sessions each day containing 4 cycles of intense activity of 2 minutes and 3 cycles of active rest of 2 minutes. The third part, in three training days, included 5 intense cycles and 4 active rest cycles. The fourth part consisted of two training days with the same intensity as the third part but with an increase in the frequency of activity and active rest in each session.
Results: One-way analysis of variance test showed that two weeks of intense intermittent training, although reducing the heart attack area of rats, however, it did not cause significant changes in MDA, SOD and GPx enzymes following acute myocardial infarction between stroke-exercise and stroke groups.
Conclusion: Intense intermittent exercise reduces heart damage in myocardial infarction, and this reduction occurs independently of changes in oxidative and antioxidant factors.
