Showing 10 results for KHaksarian
Mojtaba Khaksarian, Mohammad Javan, Ali Sonboli, Fereshte Motamedi,
Volume 5, Issue 3 (1-2004)
Abstract
Introduction: Hypericum perforatum L was coded in medicinal plants research center of Shaheed Beheshti university and using decoction method was extracted. There are many reports concerning the antidepressant effects of Hypericum perforatum L. (HP), but there are few studies indicating its antinociceptive effects of Hypericum specially Hypericum perforatum L.
Materials & Methods: In this experimental study 70 male Sprague- Dawely rats weighing 200-230g were used for all experiments. Both chronic (formalin test) and acute (tail flick test) pain models were used. In this study aqueous extract of HP extract was administered intraperitoneally (i.p.) to evaluate its antinociceptive effect.
Intraperitoneally (i.p.) administration of aqueous HP extract was assessed in three doses (200, 400 and 800 mg/kg). Antinociceptive effects compared with sodium salicylate (SS) as a positive control. The 50% letal dose (LD50) of the extract was about 6000 mg/kg.
Findings: Results of the experiments show that administration of 300 mg/kg of SS i.p. had no effect on tail-flick latency, while all doses of HP extract increased it. In both phases of formalin test, all doses of HP extract alleviated the animal’s nociception, but SS 300 mg/kg produced antinociception only in the second phase of formalin test.
Conclusion: It seems that HP extract effects on both acute and chronic pain. Its peripheral and central mechanisms of action remain to be elucidated.
Hasan Teimouri , Mojtaba Khaksarian ,
Volume 7, Issue 3 (12-2005)
Abstract
Background: Succinylcholine is the most anesthetic drug used to muscle relaxation in emergency endotracheal intubation. Unfortunately it can have serious side effects. The perpose of our study was to comparison of Atracurium + Alfentanyl with succycholine.
Materials and Methods: In this clinical trial study, one hundred patient randomly designated two group succinylcholine (control group) & Atracurium + Alfentanyl (experimental) after injecting of thiopental as a Alternative Method for R.S.I we can assess the difference between this two groups, with regarding to condition of intubations such as jaw relaxation, vocal cord movement and bucking.
Findings: Results showed that 38% of patient had mild bucking in Atr + Alf group but all patients in succylin group were not seen (p<0.0001).
Vocal cord movements was seen in expelinental group but there wasn’t in control group.
Conclusion: According to results, use of Atra + Alfen method can replace the standard method (succinylcholine) for contraindicated condition. Mild vocal cord movement and mild bucking in the Atracurium + Alfentanyl can be control by that a increase in Atracurium dose.
Afshin Nazari , Hosein Noroozi , Mohammad Movahedi , Mojtaba Khaksarian ,
Volume 9, Issue 3 (Yafteh 2007)
Abstract
Nazari A1, Noroozi H2, Movahedi M3, Khaksarian M1
1. Instructor, Department of Physiology, Faculty of Medicine, Lorestan University of Medical Sciences
2. Assistant Professor, Department of Mycology, Faculty of Medicine, Iran University of Medical Sciences
3. Assistant Professor, Department of Genetic Epidemiology, Faculty of Medicine, Lorestan University of Medical Sciences
Abstract
Background: Aflatoxin M1 is a hydroxylated form of aflatoxin B1 which is produced by Aspergillus flavus. This toxin is produced when cows or other ruminants eat foods contaminated with these mycotoxins and then excrete them in the milk. The toxin is a potent liver and kidney carcinogenetic agent.
Materials and methods: Forty two raw cows milk samples from local sources of milk collection and forty samples of commercial pasteurized market milk from Khorramabad, Lorestan, Iran were collected in summer and winter season of 2005. Twenty-one cow milk samples and 20 pasteurized milk samples in each season were analyzed for the presence of aflatoxin M1 (AFM1) by HPLC immunoaffinity columns.
Results: Four of 21 raw milk samples in summer showed AFM1 levels between 0.017-0.046 ng/ml and all samples (100%) in winter showed the presence of AFM1 levels between 0.003-0.041ng/ ml. AFM1 was detected in 55% of market pasteurized cow milk samples ranging from 0.017 to 0.533 ng/ml in summer and 100% ranging from 0.005-0.0054 ng/ml in winter.,Only one of all milk samples of pasteurized milk in summer had toxin level (0.533 ng/ml) more than the maximum permissive limit (0.5 ng/ml). No significant difference was observed among mean contamination level of raw and pasteurized cow milk in two seasons.
Key words: Aflatoxin M1, raw milk, pasteurized milk, Khoramabad, HPLC
Mojtaba Khaksarian, Mohammad Hadi Meshkatosadat , Rasoul Farzi, Farzaneh Safarpour ,
Volume 9, Issue 4 (Yafteh 2008)
Abstract
Khaksarian M1, Meshkatosadat MH2, Farzi R3, Safarpour F3
1. Instructor, Department of Physiology, Faculty of Medicine, Lorestan University of Medical Sciences
2. Associate Professor, Department of Chemistry, Faculty of Basic sciences, Lorestan University
3. M.Sc of Physiology, Staff member of Neurology Sciences Research Center, Kerman University of Medical Sciences
Abstract
Background: In previous studies, antinociceptive activity of Allium Jesdianum (AJ) has been evaluated using Formalin and Tail Flick tests. Therefore, the aim of this research is to study and analyze substances in extract and probable role of the opioidergic system.
Materials and methods: AJ was collected from Lorestan province and was coded in Agriculture College of Lorestan University, and by the use of rotary device, it was extracted. The sample of the study was a group of 120 male Sprague-Dawely rats weighing 180-220gr. and 50 other mice. AJ extract was administrated intra-peritoneally for the evaluation of its antinociceptive effects. Pain models selected were Tail Flick and Hot Plate. For the evaluation of the probable role of opioidergic Naloxone an opioidergic antagonist was used in two pain models. Sensory motor performance was evaluated using Rotarod apparatus. Substances of extract using GC/Mass apparatus were analyzed.
Results: Results of experiments showed that AJ administration increased Tail Flick and Hot Plate latencies. Naloxone pre-treatment inhibited antinociceptive effects of AJ in both pain models. Sensory motor performance was not seen. IN extract analysis Morphin Cylerit, Ethyl cinamate, Isocoinoline, Neomantol and long chain alcohol were founded.
Conclusion: In general, the experiments showed that AJ extract has antinociceptive effects that is opposite to Naloxone, and extract analysis proposed that Morphine Cylerit or Etyi Cinamate is suitable for this role.
Afshin Nazari, Mehrnosh Moghaddasi Jahromi , Asadolah Tavakoli, Naser Pajouhi, Mojtaba Khaksarian, Raheleh Assaei, Rezvan Batebi, Ali Sheikhian, Masomeh Nazari,
Volume 18, Issue 2 (9-2016)
Abstract
Background: Given the role educational system, it is necessary to most desirable design and implements activities. Internal evaluation is process in which members of the department said the group's objectives and their performance are judged and then reviewed their role and for better performance, essential steps to take.The purpose of this study was the internal evaluation of Physiology Department of Lorestan University of Medical Sciences.
Materials and Methods: The study was descriptive and cross sectional conclucted in 2014-2015. Data was collected using questionnaire and was evaluated in 6 areas. Questionnaire was prepared and drafted by some faculty members and Medical Education Development Center. Based on the Likert scale, data was classified favorable, relatively favorable and unfavorable in a range of 0 to 5 points.
Results: The results showed that the head of department area (acquired by averaging 4.23), faculty members (3.57), educational courses (3.96) and curriculums of the department of physiology (3.57) are favorable and areas of educational and research requirement and constructions (2.92) and research activities of the faculty members (2.73) are comparatively favorable.
Conclusion: According to Likert scale, department of physiology of Lorestan University of Medical Sciences was evaluated and ranked in all mentioned areas (acquired by averaging 3.39), therefore has a satisfactory level.
Hassan Sohrabian Kafraj, Abdolhosein Shiravi, Vida Hojati, Mojtaba Khaksarian, Maryam Alipour,
Volume 21, Issue 3 (11-2019)
Abstract
Background: Glioblastoma (GBM) is the most common malignant brain tumor in adults. Ginger has anti-tumor, anti-fungal, insecticidal, and anti-cancer properties. However, its anti-tumor effects on the C6 glioma cell line have not been examined. Hence, the anti-tumor effect of its hydro alcoholic extract has been investigated in the present study.
Materials and Methods: The hydro alcoholic extract of ginger was prepared. After the cultivation and proliferation of C6 glioma cells, they were exposed to concentrations of 100 to 1000 μg / ml for 24, 48 and 72 days, and the cell viability was determined by MTT method. Finally, the obtained data were analyzed using the one-way analysis of variance model.
Results: The results of MTT test showed that the hydroalcoholic extract of ginger could have dose and time-dependent anti-tumor effect on tumor cells. The highest percentage of cell death was observed with the increasing concentration of the extract and the extention of the incubation period up to 72 hours. The inhibitory concentration of cells growth (IC50) for tumor cells obtained for 24, 48, and 72 hours were 500.25, 611.118, and 733.33μg / ml respectively.
Conclusion: Since the hydroalcoholic extract of ginger in a dose and time-dependent manner inhibited the growth of C6 glioma cell lines, this extract might be effective in the treatment of brain tumors.
Mojtaba Khaksarian, Saba Hasanvandi, Roghayeh Piri, Mohammad Mahdi Sohrabifard,
Volume 22, Issue 1 (4-2020)
Abstract
Background: Nowadays, neurofeedback is used as a new method to improve the symptoms of ADHD and epilepsy. The effectiveness of this new therapeutic approach in various disorders has been investigated. The purpose of this study was to compare the efficacy of this treatment in patients with hyperactivity and epilepsy.
Materials and Methods: This study was quasi-experimental with pretest and post test and the control group. The study population comprised all the children with ADHD and epilepsy in Karaj. The sample consisted of 60 infected children (15 indivuduals suffering from ADHD, 15 people with epilepsy and 30 controls) who were selected by the random sampling method. In the pre-test, the behavioral behavior (executive summary) for children was completed. This tool reflects the teacher's view of student behaviors in the field of executive functions. In fact, it provides a tool for screening the performance problems. Executable executive functions in this log include inhibition, flexibility, emotional control, initiation, work memory, planning / organizing, inventory management and monitoring. To conduct the research, the beta / theta program was used for all the subjects. The aim was to increase theta waves and decrease beta waves. After completing 10 sessions (5 weeks and 2 sessions per week), the neurofeedback was run and the log was re-entered. Descriptive statistics (mean and standard deviation) were used to analyze the data and the one-variable covariance method was used to infer the data. Spss version 18 was used to analyze the data.
Results: The findings of the research indicated that the performance scores in the pre-test and post-test of the studied groups were significantly different )P<0.001(. Moreover, the effect of neurofeedback treatment on the improvement of executive functions in the ADHD group was higher than the epileptic and control groups )P<0.001(.
Conclusion: Based on the findings, neurofeedback is efficient but its effect is different in patients with ADHD and epilepsy. Hence, the use of neurofeedback is more effective in improving the performance of ADHD patients. These results can be useful in the field of overactive treatment using novel methods.
Zahra Nazari, Maryam Khosravi, Hedayat Sahraei, Maryam Bananej, Mojtaba Khaksarian,
Volume 24, Issue 2 (7-2022)
Abstract
Background: Depression, as a mental disorder, causes many complications in humans. Saffron has been suggested as one of the effective plants in treating various types of depression. The present study aims to assess the effect of the aqueous extract of saffron on depression caused by chronic social defeat stress (CSDS) in rats.
Materials and Methods: To induce CSDS, male Wistar intruder rats (Weight= 220-230 g) were put in the cage of male Wistar resident rats (Weight= 280-300 g) for twelve consecutive days (20 min/day). Five minutes before exposure, the intruder rats received either saffron extract (1, 5, and 10 mg/kg) or saline (1 ml/kg). After the exposure, the animals’ weight, desire for the sucrose solution, and locomotor activity were recorded. In addition, at three stages, blood samples were collected from the retro-orbital sinus of animals to evaluate the plasma corticosterone levels. Data were analyzed in SPSS software using Kolmogorov-Smirnov test and repeated measures analysis of variance.
Results: Animals in the stress group showed severe weight loss, decreased desire to drink sucrose solution, decreased mobility, and increased plasma corticosterone level (P<0.05). Administration of saffron aqueous extract with different doses improved these symptoms (P<0.01).
Conclusion: The aqueous extract of saffron can reduce depression in the animal model of CSDS through reducing corticosterone secretion in response to stress.
Amin Hasanvand, Arefeh Ghiasvand, Mohammadjavad Nourmohammadi, Fatemeh Hatami, Zahra Haghighatian, Yaser Mokhayeri, Mojtaba Khaksarian,
Volume 26, Issue 3 (10-2024)
Abstract
Background: Neuropathic pain is one of the most important chronic and pathological problems that can cause disruptions in human life. Some studies indicated that the release of inflammatory cytokines and increased oxidative activity can increase nerve damage. Adalimumab is a human anti-monoclonal drug that can cause therapeutic effects in different diseases. The present study aimed to investigate the analgesic effects of adalimumab in the chronic constriction injury (CCI) experimental pain model in rats.
Materials and Methods: A total of 20 male Wistar rats were utilized in this study and were randomly assigned to four groups: the first group served as the control, the second group underwent CCI, the third group received CCI in conjunction with adalimumab (5 mg/kg), and the fourth group received CCI with adalimumab (10 mg/kg). Behavioral assessments were conducted 4, 7, and 14 days post-CCI induction. The spinal cords were extracted after these assessments, and the supernatants were analyzed for inflammatory and oxidative enzymes. Data analysis was performed using Prism GraphPad statistical software.
Results: The analysis of the obtained data indicated that the injection of adalimumab in the third and fourth groups decreased the activity of inflammatory cytokines, such as TNF-α, IL-6, and CRP. In addition, it decreased the activity of MDA and increased the SOD and CAT enzymes. Moreover, adalimumab significantly improved the outcomes of thermal allodynia, mechanical allodynia, and thermal hyperalgesia in the CCI rats treated with this medication.
Conclusion: The administration of adalimumab can be used to treat or reduce neuropathic pain with its anti-inflammatory and antioxidant activity, along with neuroprotective effects.
Fatemeh Shiravand, Saba Hasanvand, Abolfazl Jabbar Pour, Mahboube Sahl Abadi, Mojtaba Khaksarian,
Volume 26, Issue 3 (10-2024)
Abstract
Background: Neurodegenerative diseases are a group of disorders caused by the destruction and death of neurons. They are clinically heterogeneous and can manifest in a variety of ways. Evidence suggests that inflammation plays a major role in the pathogenesis of several common neurological diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and common psychiatric disorders, such as depression, bipolar disorder, and obsessive-compulsive disorder. One of the effective and novel interventions is transcranial direct current stimulation (tDCS), which modulates central nervous system activity. This non-invasive brain stimulation method induces changes in inflammatory responses.
The present study aimed to assess e the effects of tDCS on neurodegenerative diseases caused by neuroinflammation. Despite the prominent role of inflammation in the development of neurodegenerative diseases, there is still no effective and safe treatment to control inflammatory processes in these diseases. On the other hand, considering that some inflammatory processes in the nervous system are beneficial, controlling inflammation rather than suppressing it is a more effective treatment approach. It seems that tDCS induction can be a safe and effective method for the relative improvement of some symptoms of neurological and psychiatric diseases.
