Showing 11 results for Khosravi
Keyvan Bassiri, Mohammad Zare, Saeed Khosravi,
Volume 5, Issue 2 (1-2004)
Abstract
Introduction: Blink reflex (BR) is a new electro diagnostic test mediated through a reflex arch with fifth cranial nerve in its afferent and seventh cranial nerve in its efferent side. BR responses are designed R1 , R2 and R2c responses. Anatomic locations of this reflex arch in central nervous system are still undefined and various results have been reported in different studies, for example in hemispheric strokes, exclusive abnormalities of R2 responses or abnormalities in both R1 and R2 (unilateral or bilateral) have been reported.
Materials and Methods: Twenty patients with hemispheric strokes were evaluated during 1.5 year period and were compared with age and sex matched normal volunteers. BR was performed in similar circumstances in both groups and results were compared with each other.
Findings: BR was abnormal in 19 patients and was normal in only one patient. R1 response was normal in 18 patients and was prolonged in two patients. R2 response was absent or prolonged in 18 patients (in 15 patients bilaterally) and was normal in two patients. The most prevalent observed risk factors in the study population were Hypertension and Diabetes mellitus respectively.
Conclusion: BR was abnormal in 95% of the patients and R2 response abnormalities were detected in 90% of the patients (Bilateral in 75%). The most common observes pattern of BR abnormalities in hemispheric strokes was bilateral absence or prolongation of R2 responses.
Nader Azadbakht , Kobra Khosravinegad , Mohammad Javad Tarrahi ,
Volume 10, Issue 3 (yafte 2008)
Abstract
Azadbakht N1, Khosravinegad K2, Tarrahi MJ3 1. MSc in plant pathology, Khorramabad, Iran 2. BSc in livestock sciences, Khorramabad, Iran 3. Instrustor, Department of Epidemiology, Faculty of Health, Lorestan University of Medical Sciences , Khorramabad, Iran Abstract Background: Aflatoxins belong to a group of toxins called mycotoxins that infection with them can cause complications in humans such as immunity weakness, lung syndrome, liver cancer, esophagus cancer and hemagglutination, and are inhibitor of RNA and protein, as well as cause numorous complications in genital, respiratory and the digestive systems and because of their poisoning and carcinogenic and tumorigenic properties, cause numorous complications in livestock. This research was carried out to determine the rate of Aflatoxine contamination of bread losses in Lorestan province and its comparison with standard levels reported by WHO and FAO. Materials and methods: This study was done by field and laboratory method on 180 samples of losses dried bread in 2009 with randomized distribution in Lorestan provine and detection of samples contamination to aflatoxin was done by HPLC floresence apparatus. Data was analyzed by SPSS software (α=5%). Results: The median rate of types of aflatoxin: B1,B2,G1 and G2 total types of aflatoxin in bread losses (infected, semi-infected and safe) in Lorestan were 22.5304,2.4369,0.1923,0.1022 and 25.2636 (µg/kg). Average of minimum and maximum infection to aflatoxin with all types of aflatoxin belonged to Khorramabad (42.9403 and 47.7153 µg/kg) and Borujerd (1.8611 and 1.9833) respectively. Average rate of aflatoxin type B1 in infected, semi-infected and safe bread are 64.0536, 1.9167, 0.5629 (µg/kg) and average rate of all types of aflatoxin in infected, and safe breads were: 72.0257,1.9990 and 05753 (µg/kg). Also rate of aflatoxin B1 in 29 out of 180 samples are more than standard level and total rate of different types of aflatoxin in 18 samples were more than standard levels. Conclusion: Results of the carried out studies showed that the milk of the cows feeding dried bread contains large amount of Aflatoxin’s metabolites, so the consumption of losses dried bread must be forbidden for livestock and humans too.
Morteza Hossein-Zadeh , Afra Khosravi ,
Volume 10, Issue 4 (yafteh 2009)
Abstract
Background: Iron deficiency anemia is one of the most prevalent anemia in children and pregnant women in the world. It has recently been revealed that H.pylori infection is one the most important causes of anemia. Materials and Methods: In this analytical study 100 anemic children were analyzed using total Iron, Ferritin, TIBC and H.pylori IgG assay. Data were collected using a questionnaire in which the following parameters were included: age, blood group, infancy nutrition, iron consumption, fatigue, weakness, height, weight, gastrointestinal, infection, parasitic and humoral diseases and demographic information. Results: The most prevalent blood group detected in the studied cases was group O (62%) while only 3% of the individual showed AB group. 79% were breastfeed, 9% bottle-feed, 12% used both breast and bottle-feeding methods. 37% of the children consumed iron during breastfeeding. A significant relationship was observed for the iron level in serum, ferritin, level of TIBC and elevated level of IgG titer to H.pylori. Discussion: The results of this study indicated that the significant relationship between the iron level, IgG titer and h.pylori infection rate could be referred to as an important factor influencing the anemia rate so that H.pylori IgG test could be checked for anemia together with the other routine tests
Afra Khosravi , Eghbaleh Asadollahy , Poul Oniel,
Volume 10, Issue 4 (yafteh 2009)
Abstract
Background: Resistance to chloroquine (CQ) in Plasmodium falciparum malaria has become a major health concern of the developing countries.This resistance has prompted a re-examination of the pharmacology of alternative antimalarials that may be effective against resistant strains. Amodiaquine (AQ) is a 4-aminoquinoline antimalarial which is effective against many chloroquine-resistant strains of P. falciparum. However, clinical use of AQ has been severely restricted because of associations with hepatotoxicity and agranulocytosis. The aim of this study was to examine the effects of replacing the 4’OH function of amodiaquine with either chlorine or fluorine. Materials and Methods: A successful four-step synthesis of a new series of 4-chloro analogues has been designed and applied to the synthesis of an array of 10 analogues. Malaria parasites were maintained in continuous culture using the method of Jensen and Trager. Cultures were grown in flasks containing human erythrocytes (2-5%) with parasitemia in the range of 1% to 10% suspended in RPMI 1640 medium supplemented with 25 mM HEPES and 32 mM NaHCO3, and 10% human serum (complete medium). Cultures were gassed with a mixture of 3% O2, 6% CO2 and 91% N2 and were kept in a 30 degree temperature. Results: It is apparent that several analogues had very potent antimalarial activity against both strains of the parasite. In particular 5b, 5c and 5i were not only active in the single nanomolar range, but they also displayed little cross-resistance. Against the sensitive HB3 strain, these analogues were superior to chloroquine and slightly more potent than amodiaquine. Activity was reduced when the side-chain was large (eg. dibutyl analogue and pyridine analogues, 5g and 5j respectively). Discussion: In a four - step Process, 10 different chloro - amodiaquine were synthesized which showed (in vitro) Promising effects against chloroquine resistant strains of Plasmodium falciparum. It is clear that the 4’chloro series has several members with higher or equivalent activity to amodiaquine (and 4(b)). In particular, given the metabolic resilience of the N-tert butyl side-chain (as seen in metabolism studies with 4b) analogue 5b looks like an excellent candidate worthy of further investigation.
Afra Khosravi , Eghbaleh Asadollahi , Poul Hommel,
Volume 11, Issue 1 (yafteh 2009)
Abstract
Background: Plasmodiom falciparum MSP-2 is taken into accout as one of the candidates of vaccine agaist malaria and various studies indicated immunizing effect of different domains of the molecule. Monoclonal antibody against MSP-2 is a confident and definite method to confirm this Immunization.
Materials and Methods: P. falciparum Parasite was Prepared in a Culture in CludingRPMI1640 and Schizontantingens extracted and injected into the mice. Then B Lyphocytes of immunized mice were extracted from their spleen and the fusion was Performed using NS-1 and monoclonal antibody to MSP-2 was Produced.
Results: Anumber of monoclonal antibody to MSP-2 weres Produced which confirmed efficiency and Immunizing effects of various domains of MSP-2 molecule.
Katayon Bakhtiyar , Mohammad Hosein Gharouni, Heshmatollah Khosravinia, Ehsan Rashidian ,
Volume 14, Issue 1 (6-2012)
Abstract
Background : Children's diarrhea is one of the major health problems worldwide, especially in developing countries, accounting for nearly 4-5 million deaths per year.Campylobacter jejuni is a common human bacterial pathogen, which plays at least the same leading role to Salmonella and Shigella as the causative agent of infectious diarrhea. Regarding limited studies on different epidemiologic aspects of this bacterium in Iran, this research carried out to determine infectious enteritis caused by Campylobacter Jejuni in children with diarrhea in Khorramabad city.
Materials and Methods: In this study the descriptive survey of the diarrhea caused by Campylobacter jejuni in children less than 12 years of age in Khorramabad city was conducted between September 2004 and September 2005. Stool specimens were collected from patients referred to medical laboratory of Shahid Madani children’s hospital and the correspondent laboratories with clinical symptoms of acute diarrhea. The specimens were transferred to microbiological laboratory of the veterinary faculty of Lorestan university in an attempt to isolate and identify Campylobacter jejuni species.
Results:One hundred-thirty out of the total 321 collected specimens (40.5%) were concerned to the female and 191 specimens (59.5%) to the male patients. Campylobacter jejuni species were isolated from 19 (5.92%) of the total collected specimens from which 11(3.43%) and 8 (2.49%) were associated to the female and the male children, respectively.
Maximum of the positive cases were reported in the children aged less than 1 year (1.87%) and 1-3 years old (1.87%) that difference based on age groups was significant.
Conclusion: According to the findings of the present investigation, the prevalence rate of Campylobacter enteritis in children less than 12 in Khorramabad in 2007 was 5.92 % which is same as the findings of similar studies in Zahedan (6%), Tehran (5%), Sari (4.8%) and Shiraz (5%).
Mojgan Khosravi, Sara Shojaei Zarghani , B Sc Parisa , Mohammadi Nafchi,
Volume 17, Issue 4 (2-2016)
Abstract
Background : There is contradictory evidence regarding the effects of calcium intake on the weight and body fat percentage. The objective of the present study was to investigate the relationship between calcium intake and anthropometric indices among adults.
Methods and Materials: The present cross-sectional study was conducted on 94 employees of the Lorestan university of medical sciences. The height and waist circumference of samples were measured using standard procedure, and weight, fat percentage, and visceral fat area were measured using a body composition analyzer machine (ioi 353). To determine the amount of calcium intake, a valid and reliable food frequency questionnaire was completed for each individual and the obtained data were added to the Nutrition 3 application.Then, the data were analyzed using SPSS 19.
Results: Based on the results, 44.7% of the participants had normal weight, while 55.3 percent were overweight or obese. The mean calcium intake for men and women were 982.69 and 1124.16 mg per day, respectively. No significant relationships were found between calcium intake and the variables of BMI, waist circumference, body fat percentage, and visceral fat area in men and women.
Amir Khosravi, Omid Ali Omidali, Bahram Rasoulian, Seiros Choobineh,
Volume 19, Issue 1 (6-2017)
Abstract
Background : Despite regular exercise benefits, acute exhaustive exercise elicits oxidative damage in liver. The present study aims to investigate the effects of a week aqueous Saffron extracts consumption on malondialdehyde (MDA) and superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) Antioxidant enzymes alterations content of liver of young male rats following an acute bout of exhaustive exercise.
Materials and Methods: We randomly classified 48 Wistar male rats were assigned into following three groups 16 rats per group: 1) control 1 (saffron extract solvent); 2) control 2 (saffron extract solvent+ training); 3) experimental (aqueous saffron extract, 50 mg/kg + training).After a week, half of each group were killed without exhaustive, but the remaining rats (control 2 and experimental) were killed immediately after performed an acute bout of exhaustive exercise and SOD, CAT , GPx and MDA in their liver were measured.
Results: The MDA level and anti-oxidant enzymes activities didn’t change significantly, in the liver tissue in experimental group unlike control group of rats following an acute bout of exhaustive exercise
Conclusion: The consumption aqueous extract of saffron stigma in rats leads to the reinforcemen of the antioxidant defense system and prevented the MDA level and anti-oxidant enzymes defense system in the liver tissue of rats following an acute bout of exhaustive exercise.
Mozhgan Khosravi,
Volume 19, Issue 3 (special issue of passive defense 2017)
Abstract
Background: Bioterrorism means the deliberate release of highly pathogenic microorganisms or their poisons that leads to the death of human beings, plants, and animals.
Materials and Methods: This was a review article conducted using library resources.
Results: One way of releasing biological agents among the target population is the deliberate contamination of water and food. Water and food contaminated in bioterrorist activities are not recognizable by organoleptic properties, and in most cases, they emerge silently, suddenly and without apparent changes (color, odor, taste). Water treatment centers, wells used to supply potable water, purified water tanks, storehouses, and the various stages of production, storage and distribution of food in food factories and imported food are the best places to introduce pathogenic agents, and the more rudimentary, non-industrial, and non-sanitary the control systems and mechanisms are more vulnerable to infiltrate and sabotage they become. Given the high resistance of these pathogens to drugs and treatment, the unlikeliness of making rapid diagnoses, the low dosage needed to induce infections, and the absence of vaccines for many of these pathogens, the best method is to prevent the occurrence of such diseases
Conclusion: Considering the importance of this issue and its irreparable damage and the great number of enemies that the Islamic Republic of Iran's sacred government has, this article discribes this phenomenon and ways of controlling and preventing it.
Amir Khosravi, Fatemeh Omidali, Bahram Rasoulian, Sirous Choobineh,
Volume 19, Issue 4 (10-2017)
Abstract
Background: Some scientific data have been reported the positive effects of natural antioxidants on modulating the Total Antioxidant Capacity and muscular damage indicators.
The aim of this research was to examine the effects of Short-Term Grapefruite juice Supplementation on Lipid Peroxidation and Total Antioxidant Capacity and some muscular damage indicators in young men following a session of intensive an resistanceactivity.
Materials and Methods: In a randomized double-blind study twenty young men students were randomly divided into two equal groups of experimental, and control. After supplementation period, subjects performed a session of intensive resistance activity at 85% of one repetition maximum. Changes in the Total Antioxidant Capacity and malondialdehyde and muscular damage indicators (Lactate dehydrogenase and Creatine Kinase) were determined in three phases.
Results: The results showed that changes in the Total Antioxidant Capacity and malondialdehyde after exercise not significantly in the supplementation group, but significantly in the control group. Also, changes in plasma Lactate dehydrogenase and Creatine Kinase after activity were significantly in the control and supplementation groups.
Conclusion: It seems that Short-Term Grapefruit juice supplementation will be useful for improving levels of plasma Total Antioxidant Capacity and thereby inhibiting exercise-induced lipid peroxidation and modification in plasma increased Lactate dehydrogenase and Creatine Kinase after intensive resistance training.
Zahra Nazari, Maryam Khosravi, Hedayat Sahraei, Maryam Bananej, Mojtaba Khaksarian,
Volume 24, Issue 2 (7-2022)
Abstract
Background: Depression, as a mental disorder, causes many complications in humans. Saffron has been suggested as one of the effective plants in treating various types of depression. The present study aims to assess the effect of the aqueous extract of saffron on depression caused by chronic social defeat stress (CSDS) in rats.
Materials and Methods: To induce CSDS, male Wistar intruder rats (Weight= 220-230 g) were put in the cage of male Wistar resident rats (Weight= 280-300 g) for twelve consecutive days (20 min/day). Five minutes before exposure, the intruder rats received either saffron extract (1, 5, and 10 mg/kg) or saline (1 ml/kg). After the exposure, the animals’ weight, desire for the sucrose solution, and locomotor activity were recorded. In addition, at three stages, blood samples were collected from the retro-orbital sinus of animals to evaluate the plasma corticosterone levels. Data were analyzed in SPSS software using Kolmogorov-Smirnov test and repeated measures analysis of variance.
Results: Animals in the stress group showed severe weight loss, decreased desire to drink sucrose solution, decreased mobility, and increased plasma corticosterone level (P<0.05). Administration of saffron aqueous extract with different doses improved these symptoms (P<0.01).
Conclusion: The aqueous extract of saffron can reduce depression in the animal model of CSDS through reducing corticosterone secretion in response to stress.
