Yafteh

Background: Prostate cancer is the second most prevalent canceramong men and the eighth leading cause of death in Iran. In pathological conditions, angiogenesis increases the chance of metastasis and thus spreads cancer. The aim of the present study was to examine the effects of 10 weeks of resistance training on some angiogenesis factors among men affected by prostate cancer.
Materials and Methods: Twenty men with prostate cancer aged between 55 and 62 were selected and randomly divided into control (n=10) and resistance training groups (n=10). The experimental group performed 10 weeks of resistance training, three sessions per week. Each exercise includes three sets of twelve repetitions with the intensity of 50-65 percent of 1RM. In order to measurement of NO, FGF and VEGF, blood samples were taken from the participants after 12 hours fasting state 24 hours before and 48 after the last training. For comparison of means between and within group's independent and dependent T test were used, respectively.
Results: The results showed that ten weeks of resistance training significantly increase the levels of VEGF ( P=0.0001), FGF (P=0.0001) and NO (P=0.0003) in men suffering from prostate cancer.
Conclusion: It appears 10 weeks of resistance training cause increase the level of angiogenesis factors, muscular strength and mass and decrease fatigue in men affected by prostate cancer.

Background: Breast cancer, which is a major cancer for women, affects the angiogenesis process. Exercise training can decrease the process of angiogenesis in tumor tissue. The aim of present study was to investigate the effects of 8 weeks of aerobic training on HIF-1α, miR-21 and VEGF gene expression in female Balb/c mice with breast cancer.
Materials and Methods: 16 female Balb/c mice (age: 3-5 weeks and weight: 17/1 ± 0.1 g) were selected and randomly divided into two groups: aerobic training and control. The aerobic training involved running with intensity of 14-20 m/min for 5 sessions per week over 8 weeks. The gene expression of HIF-1α, miR-21 and VEGF was examined by RT&PCR. The repeated measurement ANOVA, Bonferroni post hoc test and the independent T-test were used to analyse the data, with a significant level set at p<0.05.
Results: The results showed that aerobic training induced significant differences in the growth of tumor volume and an increase in HIF-1α. In addition, aerobic training caused a significant decrease in the gene expression of miR-21, whereas the changes in gene expression of VEGF were not significant.
Conclusion: It appears that aerobic training caused a reduction in the gene expression of miR-21 and VEGF, which in turn, induced a decrease in the tumor volume and a corresponding improvement in the cancer