Background: The predictive role of mean platelet volume (MPV) and red cell distribution width (RDW) in cardiovascular diseases has been proven. High-intensity interval training (HIIT) is a sustainable and effective method for improving cardiorespiratory fitness. Therefore, the present study aimed to investigate the effect of eight weeks of HIIT on MPV and RDW in inactive, normal-weight, and obese women.
Materials and Methods: In this semi-experimental research, 24 participants were voluntarily selected from a population of inactive, healthy, obese women and healthy women of normal weight aged 30 to 45 years. They were divided into two experimental groups, each consisting of 12 participants (normal-weight and obese). Both groups were in a circuit HIIT protocol for eight weeks, three sessions per week with an intensity of 90% HRmax for related exercises. Blood sampling was taken on two occasions: once before and once after a 12-hour fasting period and again 48 hours after the last training session. The analysis of covariance (ANCOVA) statistical test was employed to analyze variables at a significance level of P < 0.05.
Results: The results indicated that there was a statistically significant difference between the two obese and normal weight groups in the average decreases in MPV (P=0.045), red blood cell distribution width (RDW) (P=0.001), and high-density lipoprotein (HDL) (P=0.045).
Conclusion: High-intensity exercise may modulate MPV and other cardiovascular disease risk factors, such as high body mass index and high body fat percentage in middle-aged women, suggesting an effective, inexpensive, and accessible non-pharmacological method for reducing the risk of cardiovascular diseases.
