Dr Majid Tavafi, Dr Hasan Ahmadvand, Ahmad Tamjidipoor, Dr Alireza Khalatbari, Dr Bahram Delfan, Mehdi Birjandi,
Volume 12, Issue 3 (3-2011)
Abstract
Diabetic nephropathy is the common cause of leading to end stage of renal disease.Satureja Khozestanica essence for the first time used as antioxidant, antidiabetic and anti-inflammatory agent for inhibition of diabetic nephropathy. Materials and Methods: 40 male rats were uninephrectomized from left flank .The rats were divided into four groups randomly(ten per each group), group one as control, group two diabetic without treatment and groups three and four, treatment with Satureja essence with 250 ppm or 500 ppm in drinking water respectively. Diabetes was induced in the second, third and fourth groups by alloxan injection subcutaneously .After 8 weeks treatment of serum malondialdehyde was measured. Kidney paraffin sections were prepared and stained by Periodic Acid Schiff method.Glomerular volume ,intraglomerular mesangial volume and volume of glomerular capillary were estimated by stereological rules. Data were compared by SPSS13 software and Mann Whitney nonparametric test at p<0.05. Results: Glomerular hypertrophy, mesangial expansion and reduce of glomerular capillary volume in the groups that treated by Satureja essence, significantly were inhibited in comparisor with diabetic untreated group but it cannot be saved at level of control group significantly(p<0.05). The level of serum malondialdehyde in treated groups was maintained at the level of control group significantly (p<0.05). Conclusion: Satureja Khozestanica essence significantly can inhibit glomerular hypertrophy, mesangial expansion and save glomerullar capillary volume in diabetic rats significantly.
Maryam Sadat Miraghajani , Ahmad Esmaillzadeh , Mozhgan Mortazavi, Maryam Mirlohi , Leila Azadbakht ,
Volume 15, Issue 1 (5-2013)
Abstract
Background : Nephropathy is a common complication of diabetes and it is the major cause of disability and death among these patients. We aimed to determine the effects of soy milk on inflammation, coagulation and oxidative stress among type 2 diabetic patients with nephropathy.
Methods: This randomized crossover controlled clinical trial was conducted on type 2 diabetic patients with nephropathy. This study had two trial phases, each for 4 weeks and one washout period for two weeks. Patients were randomly assigned to consume a diet containing soy milk, or a diet containing cow’s milk.
Results: Soy milk consumption, in comparison to cow’s milk, resulted in a significant reduction in D-dimer level. This significant effect remained even after adjustment of cofounding factor (carbohydrate intake). However, soy milk consumption had no significant effects on inflammation and oxidative stress levels.
Conclusion: Soy milk consumption for 4 weeks could decrease serum D-dimer level in type 2 diabetic patients with nephropathy.
