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Showing 7 results for Fertility

Fatemeh Yari , Hedayat Nazari , Hosein Khedmat , Abbas Tavalaee , Saeed Foroghi , Fatemeh Janani ,
Volume 6, Issue 1 (6-2004)
Abstract

Background: Women suffer more often from depression than men. Social research suggests that high androgen levels cause aggressive behavior in men and women, and consequently cause depression. The purpose of this study was to determine serum levels of androgens, especially testosterone, in patients with depression. Material and methods: In this case-controlled study, we measured serum testosterone and dehydroepiandrosterone sulfate levels in 30 women with depression and 30 control subjects of the same age, weight, body mass index (BMI) and menstruation cycle. Results: Total testosterone and free testosterone levels were significantly higher in patients with depression (202.3 ng/dl and 0.4 ng/dl respectively) than in the control group (140.3 ng/dl and 0.1 ng/dl respectively). There was no significant difference in dehydroepiandrosterone sulfate levels. Conclusions: This study may indicate a role of androgen, especially testosterone in the pathogenesis of depression.
Nilofar Satarzadeh , Nasim Bahrami , Fatemeh Ranjbar Koch-Saraei , Morteza Ghojazadeh,
Volume 9, Issue 2 (9-2007)
Abstract

Satarzadeh N1, Bahrami N2, Ranjbar Koch-saraei F3, Ghojazadeh M4

1. Instructor, Department of nursing, Faculty of nursing and midwifery, Tabriz University of medical sciences

2. Instructor, Department of parastari, Faculty of nursing and midwifery,Ghazvin University of medical sciences

3. Assistant professor, Department of psychology medicine , Faculty of medicine , Tabriz University of medical sciences

4. Assistant professor, Department of physiology , Faculty of medicine , Tabriz University of medical sciences

Abstract

Background: Some studies show the depression, stress, low self-esteem, sexual dissatisfaction may be psychological outcomes of infertility. Depression and sexual satisfaction play a significant role in the life of infertile couples, their infertility treatment follow- up and in their hopefulness for the future. The present study was carried out to determine and comparing the depression and sexual satisfaction among infertile and fertile couples referring to Alzahra educational center in Tabriz.

Materials and methods: This is a comparative- descriptive study in which depression and sexual satisfaction rate were studied and analyzed in 150 infertile versus 150 fertile couples. Sample selection was randomized. Data gathering was done by using questionnaire including 3 parts( Demographic characteristics of couples, Beck Depression Inventory and Larson standard questionnaire for determining sexual satisfaction). All data gathered for this study was analyzed by using descriptive statistically methods, mean difference tests and also relation test.

Results: The BDI mean difference between infertile and fertile men and between infertile and fertile women was significant (p=0.011,t=2.54in men & p<0.005, t=3.68in women). But the difference between sexual satisfaction mean difference in infertile and fertile men and between infertile and fertile women was not statically significant (p=0.707, t=0.377 in men & p=0.370, t=0.898 in women). Mean difference in infertile women was higher than their husbands but sexual satisfaction score in men and women was not statistically significant. Also there was a negative correlation between sexual satisfaction and depression.

Conclusion: Infertile couples are indigent to exact care and treatment about their psychological problems. Presence of expert counselors in infertility treatment teams for diagnosing and treating these patients before any delay, is quite necessary.


Fateme Yari, Dr Masoume Ghafarzadeh, Dr Sepideh Vahabi, Dr Hasan Vaezinezhad,
Volume 13, Issue 1 (6-2011)
Abstract

The aim of this work was to evaluate the efficacy of adding Dexamethazone (DEX)) to Clomiphene citrate (CC) in polycystic ovary syndrome (PCOS) with normal dehydroepiandrosterone sulphate (DHEAS) in induction of ovulation. Materials and Methods: 120 infertile women with PCOS were randomly assigned into two groups. Group I: Clomiphene citrate 100 mg/day was given from day 3 to day 7 of the cycle and DEX 1 mg/day from day 3 to day 12 of the cycle. Group II: Same protocol of CC combined with placebo (Folic acid tablets) was given from day 3 to day 12 of the cycle. The main outcome was ovulation. Secondary measures included number of follicles >18 mm, pregnancy rate and ovarian follicular response were monitored by ultrasound. Results: There were no statistically significant differences between groups as regards age, duration of infertility, BMI, menstrual pattern, serum DHEAS. The mean number of follicles >18 mm were significantly higher in the DEX group than in the placebo group (p=0.059). Similarly, there were significantly higher rates of ovulation and pregnancy in the DEX group. Dexamethazone was very well tolerated as no patients complained of any side effect. Conclusion: Induction of ovulation by adding DEX to CC in PCOS with normal DHEAS is associated with higher ovulation and pregnancy rates and seems to be an effective, cheap and simple method.
Dr Farhad Shahsavar, Tomaj Sabooteh,
Volume 13, Issue 1 (6-2011)
Abstract

Antisperm antibodies (ASA) occur in men and women and may significantly impair fertility. In this case, the testis is an immunologically privileged site where germ cell antigens are protected from autoimmune attack. However, due to disruption of the blood-testis barrier occurring from testicular injury, or as a consequence of trauma to the epididymis or vas deferens many testicular proteins get autoantigenic during immunological challenges resulting in the formation of ASA in the blood serum, seminal plasma or located on the sperm membrane. ASA have also been reported to be associated with inflammation, cryptorchidism, varicocele and surgical intervention in the genital organs. ASA may interfere with different sperm functions, which are essential for the fertilization process.This review article will help to increase our understanding of the specific mechanisms that elicit the autoimmune response to sperm and of the pathogenesis of ASA that leads to an antibody-mediated infertility.


Dr Abolreza Kheirollahi , Dr Farhad Shahsavar, Tomaj Sabooteh ,
Volume 13, Issue 2 (8-2011)
Abstract

Immunoinfertility because of antisperm antibody (ASA) is one of the important causes of infertility in humans. The incidence of ASA in infertile couples is 9-36% depending on the reporting center. The prevalence of ASA is 8-21% in the infertile male partners and 6-23% in the infertile female partners. There are several methods to detect ASA. In the past, the clinical interest in ASA was hampered by the fact that a standardized assay for the detection of ASA was lacking. However, it has to be clarified whether each antibody binding to an antigen, which is identified on the sperm surface, also influences sperm function. Several methods have been reported for treatment of immunoinfertility. Most of the available techniques have side effects, are invasive and expensive, have low efficacy, or provide conflicting results.This review article will help to increase our knowledge about diagnosis and treatment methods of ASA.
Soyar Sari,
Volume 19, Issue 1 (6-2017)
Abstract

Background : Infertility is a multifactorial disease. Hormonal disorders and genetic factors are important in female infertility. Development and maturation of ovulation are depending on the molecular signaling pathways in response to androgens. Over hundreds of mutations leading to resistance gene function in androgen receptor (AR) has been recorded. One of them is polymorphic region 5'UTR. Thus regarding to the role of androgen receptor in infertility, the aim of the present study was to investigate the association between gene mutations AR and infertility in Iranian women

Materials and Methods: In this study of 50 infertile women and 80 healthy women as a control, blood samples were taken. After extraction of DNA, PCR method was used to determine the AR gene mutations.

Results: In the present study in '5UTR area at position +25 androgen receptor gene a T nucleotide deletion was observed. , therefore single nucleotide mutations did not change in the androgen receptor gene expression, so indicates the lack of communication between the AR gene mutations in the promoter region of 23 to 214+ in women with infertility. According to the results of this study are significant differences between the two groups of patients and healthy women was not found (P=0.5).

Conclusion: Results indicated no correlation between mutations in the promoter region of 23 to 214+ AR genes in the population studied women with infertility


Meysam Behzadifar, Saeed Shahabi, Ahad Bakhtiari, Samad Azari, Masoud Behzadifar,
Volume 25, Issue 4 (2-2024)
Abstract

Background: The population of any country plays a crucial role in its economic, social, cultural, and political development. A young population enhances the workforce and economic dynamism of the country. Changes in lifestyle and a series of population, economic, and political policies in recent years have exposed Iran to the risk of population aging and demographic warnings from social researchers. The situation is such that population experts unanimously believe that if the current trend of increasing births and population growth continues, the country will face a major population crisis in the next 30 years. The present study examined the challenges and policy solutions in the field of Iran's population, considering a densely populated future. Considering the age pyramid between 1990 and 2000, Iran has experienced significant population growth, providing an effective and active workforce for the country. According to statistical models, Iran's population is projected to age significantly by 2030 and 2050. The complex issue of increasing fertility and population growth requires comprehensive and balanced measures. Promoting public awareness, financial support for families, social security provision, gender balance, housing facilities, population research, rural development, and collaboration with non-governmental organizations can be considered appropriate policies to increase fertility in Iran. The population issue should not be politicized, with some opposing and others supporting it; everyone should collaborate to address this significant gap. Considering the serious concerns and warnings of the Supreme Leader regarding population aging and the expressed concerns about the decline in population and the inadequacy of the current situation, policies for increasing fertility and population growth are on the agenda. However, all organizations, agencies, and individuals who can contribute to the realization of these policies must actively and seriously participate.



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