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Showing 7 results for Type 2 Diabetes
Relationship between dietary intake and serum level of chromium with serum glucose, lipid profile and HbA1c in patients with type II diabetes
Esmaeel Yossefi-Rad , Javad Mohtadi-Nia , Akbar Ali , Asgarzadeh ,
Volume 11, Issue 2 (4-2009)
Abstract

Background: Studies indicate that there might be relations between the level of chromium in body and risk factors of diabetes. The purpose of this study is to investigate the relation between the food intake and serum level of chromium with the lipid profile, HbA1c, and glucose in patients with type 2 diabetes.

Materials and Methods: The subjects under investigation consist of 30 patients (15 females, 15 males) aged 30-60, with type 2 diabetes and a control group of 30 non-diabetic people (15 female, 15 males).They were matched for age, gender and BMI. From each participant, a 3-day 24-hour food recall was filled. Moreover, blood sample was taken to measure blood levels of sugar, HbA1c, lipid profile and chromium.

Results: The mean of serum chromium in diabetic group was 0.80 ± 0.28 μgr/dl and 1.19 ± 0.33 μgr/dl in control group, hence significantly lower in diabetic

group(P < 0.001). Dietary intake of chromium was not significantly different between the two groups. The correlation test indicated that there was no significant association between serum level of chromium and its dietary intake with fasting blood sugar (P = 0.706), HbA1c (P = 0.927), serum level of TG (P = 0.663), total cholesterol (P = 0.707), HDL-C (P = 0.209) and LDL-C (P = 0.365).

Conclusion: There was significant difference in the serum level of chromium between the diabetic group and control group although there existed no difference between dietary chromium intake of them. This is probably due to the increase of urinary excretion of this element in the diabetics.


The effects of probiotic yoghurt on C-Reactive Protein in type 2 diabetic patients
Hanoyesadat Ejtahed , Javad Mohtadi Nia , Aziz Homayouni Rad , Mitra Niafar , Mohamad Asghari Jafarabadi ,
Volume 15, Issue 3 (9-2013)
Abstract
Background: Chronic inflammation plays a major role in the progression of diabetes and its cardiovascular complications. The aim of the present study was to investigate the effects of probiotic yoghurt on blood sugar and C-Reactive Protein concentration as inflammatory factor in type 2 diabetic patients. Materials and Methods: This double-blind, randomized clinical trial was conducted on 60 type 2 diabetic patients (23 males and 37 females) in Sina hospital in Tabriz. Subjects in intervention group consumed daily 300 gram of probiotic yoghurt containing Lactobacillus acidophilus LA-5 and Bifidobacterium lactis BB-12 and subjects in control group consumed daily 300 gram of conventional yoghurt for 6 weeks. Dietary intakes, anthropometric measurements and biochemical parameters were measured at the baseline and at the end of the study. Statistical analyses were performed by SPSS software using analysis of covariance and paired samples T-test. Results: Probiotic yoghurt consumption significantly decreased C-Reactive Protein concentration (P<0.05).The mean fasting blood sugar and glycosylated hemoglobin were significantly lower in probiotic yoghurt group compared with the control group after intervention (P<0.05 Conclusion: Consumption of probiotic yoghurt improved C-Reactive Protein concentration in type 2 diabetic patients. Probiotic yoghurt consumption is recommended as auxiliary therapy in type 2 diabetic patients.
The relationship between visfatin levels and Anthropometric parameters, and insulin resistance in women with prediabetes and type 2 diabetes
Maryam Ashoori, Masoumeh Nezhadali, Maryam Shiehmorteza,
Volume 20, Issue 3 (10-2018)
Abstract
Background: Visfatin is a protein secreted by visceral fat, which plays an important role in the pathogenesis of type 2 diabetes mellitus. Visfatin is also known as Pre-B Cell Colony Enhancing Factor or Nicotinamide Phosphoribosyl Transferase.  Visfatin is widely expressed in the visceral adipose tissue and has insulin-like metabolic functions. However, its pathophysiological role in human is still unknown. The aim of this study was to evaluate the relationship between plasma visfatin and obesity, and type 2 diabetes.
Materials and Methods: This case-control study was conducted on 50 women with pre-diabetes and type 2 diabetes, and 50 healthy women. Visfatin and insulin levels were measured using a Mercodia ELISA kit (Mercodia Company, Sweden). The weight, height, waist circumference and FBS were determined using standard methods. Data was analyzed using SPSS software (Version 19).
Results: According to the data, plasma visfatin levels increased in patients with prediabetes and type 2 diabetes compared to the control group (p<0/05). There was a meaningful correlation between visfatin and BMI, weight, waist circumference and HOMA-IR (p<0/05). No correlation was found between visfatin and FBS, and insulin in patients with prediabetes and type 2 diabetes.
Conclusion: These results suggest that visfatin levels correlate with BMI, weight, and waist circumference, and can be used as a marker for the diagnosis and treatment of type 2 diabetes.

Medication Adherence and its Related Factors in Patients with Type 2 Diabetes
Afsaneh Badrizadeh, Hasan Rezaii Jamaloi, Mostafa Khanzadeh, Saeid Foroughi, Mandana Saki,
Volume 23, Issue 2 (5-2021)
Abstract
Background: One of the public health challenges in the worldwide is diabetes, and adherence to treatment is crucial. Adherence to treatment can help reduce the complications of the disease. Therefore, this study was performed to evaluate the status of adherence to treatment among patients with type 2 diabetes in Khorramabad.
Materials and Methods: In this cross-sectional study, 392 men and women with type 2 diabetes referred to comprehensive health centers in Khorramabad between May and August 2016 were studied. Demographic questionnaire and Morisky Medication Adherence Scale (MMAS-8) were used to collect data. Version 22 SPSS and descriptive analysis were used to analyze the data. Significance level in the present study was less than 0.05. Descriptive tests, Chi-square, Fisher's exact test, and independent t-test were used.
Results: The mean age of study participants was 56.03 ± 10.91. 68.9% (270 people) were women and 31/1% (122 people) were men. According to the score obtained from the Morisky questionnaire, a total of 219 patients (55/9%) followed the desired treatment and 173 (44/1%) followed the unfavorable treatment. There was a significant relationship between patients' adherence to treatment with the variables of gender, marital status, educational status, and their monthly income. No statistically significant between age and employment status with adherence to treatment were observed.
Conclusion: Findings of this study showed that adherence to treatment among patients with type 2 diabetes in Khorramabad is in a good level. Health policy makers should strive to ensure that all patients adhere to their treatment process with easy access to services and reduced costs.
Adherence to Treatment Based on Social Support and Coping Strategies in Patients with Type 2 Diabetes
Afsaneh Badrizadeh, Hasan Rezaii Jamaloi, Mostafa Khanzadeh, Saeid Foroughi, Mandana Saki,
Volume 23, Issue 3 (8-2021)
Abstract
Background: According to the growing prevalence of type 2 diabetes, the present study aimed to predict adherence to treatment based on social support variables and coping strategies to reduce the severity of this disease.
Materials and methods: In this cross-sectional study, 392 men and women with type 2 diabetes were evaluated using purposeful and convenient sampling. Wax social support and the Blings and Moss coping strategies questionnaire were used. Data were analyzed using SPSS software (version 22), descriptive statistics (frequency, percentage, and mean), and inferential statistics (Pearson correlation coefficient and regression analysis).
Results: The results indicated that the correlation between the subscales of social support and coping strategies with adherence to drug therapy was significant (P<.01). These measures could predict more than 27%) 27.1( of changes in compliance with drug treatment.
Conclusion: Social support and coping strategies can be two effective factors in promoting self-care behaviors and adherence to treatment in patients with diabetes. Including these strategies in educational, treatment, and care programs improves health and reduces long-term complications of the disease to increase the life expectancy of patients.

Effect of eight weeks of high-intensity interval training on some indices of liver mitophagy in type 2 diabetic rats
Sara Farajpour Khazaei, Javad Vakili, Vahid Sari Sarraf,
Volume 25, Issue 1 (5-2023)
Abstract
Background: Dysfunction of mitochondria is associated with such diseases as obesity, cancer, and type 2 diabetes. Training plays a major role in the improvement of mitochondrial damage and oxidative stress. Therefore, the present study aimed to investigate the effect of eight weeks of high-intensity interval training on some mitophagy indices in the liver tissue, including BNIP3 and NIX in type 2 diabetic rats.
Materials and Methods: A total of 30 three-month-old adult male Wistar rats with a weight range (250-300 g) were randomly assigned to four groups of 10 series, including healthy control (C), Diabetic control (D), and diabetic+Training (D+T). The training protocol includes running with intensity at 85%-90% of maximum speed in 6-12 two-minute intervals five days a week for eight weeks. A method based on Western blotting was used to determine changes in the expression of BNIP3 and NIX proteins in the liver tissue of rats. The one-way analysis of variance and the Bonferroni post hoc test were used to analyze the data.
Results: Diabetes increased BNIP3 and NIX proteins; nonetheless, it was not significant. The changes of NIX in the trained diabetic group were about 57% less than in the diabetic control group, and this difference was significant (P=0.033), while BNIP3, despite a 37% decrease, did not change significantly (P>0.05).
Conclusion: Eight weeks of intense intermittent training caused a significant decrease in the expression of proteins involved in mitophagy in the training group. Nonetheless, arriving at a definite conclusion on these indicators and how they are affected by different conditions depends on conducting further studies.


Effect of Linker’s Length and Sequence on the Structure and Stability of mGLP-1-DARPin Fusion Protein for Treatment of Type 2 Diabetes: A Computational Study
Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz,
Volume 25, Issue 2 (8-2023)
Abstract
Background: Glucagon-like peptide-1 (GLP-1) is a promising peptide for the treatment of type 2 diabetes mellitus. However, the potential for therapeutic use of native GLP-1 is limited due to its extremely short half-life (a few minutes). In this research, a modified protease-resistant glucagon-like peptide-1 (mGLP-1) and a human serum albumin-binding DARPin connected by flexible and helical rigid linkers were designed to increase the half-life of this therapeutic peptide.
Materials and Methods: In this study, the primary and secondary structures of designed fusion proteins were computationally studied, and some of their properties were predicted. The 3D model of the fusion proteins was created using the trRosetta server, and molecular docking between the fusion proteins and their respective receptors was conducted in the ClusPro server.
Results: The results showed that the helical rigid linker (EAAAK)3 produced the best structure and stability for the designed fusion protein, and the fusion protein could preserve the original structure of the GLP-1 and DARPin molecules. The results of protein-ligand docking confirmed the interaction of fusion proteins with respectable receptors.
Conclusion: When developing new fusion proteins, displaying and validating the domains of the designed structure is essential for comparing the efficiency and functionality with its natural homolog. The results of this study demonstrated that the mGLP-1-(EAAAK)3-DARPin fusion protein could be used in stability engineering to increase the half-life of the GLP-1 peptide drug in combination with HSA-binding DARPin.

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