Showing 8 results for Graft
Poupak Rahimzadeh , Seyed Hasan Etemadi , Valiollah Hassani , Mohamad Hosein Mirdehghan,
Volume 9, Issue 4 (2-2008)
Abstract
Rahimzadeh P1, Etemadi H1, Hassani V2, Mirdehghan MH3 1. Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Iran University of Medical Sciences
2. Professor, Department of Anesthesiology, Faculty of Medicine, Iran University of Medical Sciences
3. Resident of Anesthesiology, Iran University of Medical Sciences
Abstract
Background: Epidermolysis Bolusa is a great challenge for all anesthesiologists. In this disease even indirect touch and pressure can cause boluses or wounds on skin and membranes of body.
Case report: In this paper we introduce two Epidermolysis Bolusa patients who were brought to the operation room for the amnion graft of finger fusion.
Conclusion: For anesthetic management of these patients, when surgery does not need muscle relaxation and mechanical ventilation, Ketamine is recommended for the prevention of airway manipulation.
Rahim Mirnasuri , Gita Mokhtari , Majid Ebadifara, Zahra Mokhtari ,
Volume 15, Issue 5 (3-2014)
Abstract
Background : Cardiovascular diseases (CVD) are the most common cause of mortalily and inability. In Iran, one third of mortality causes are coronary heart diseases. So, the aim of the present study was to evaluate the effects of a Cardiac Rehabilitation program (CR) on exercise capacity (VO2max) and coronary risk factors in CABG patients aged 45-65 . Materials and Methods: Of 36 CABG patients randomly selected from Hamadan Shahid Beheshti hospital, 18 subjects as experimental group (with mean age 54.57±6.26 years and weight 72.14±10.83 kg participated in CR program), and 18 subjects as control group (with mean age 57.64±4.75 years and weight 76.5±12 kg without participation in any exercise and CR program) participated in this study based on inclusion and exclusion criteria. CR program was an eight-week involving warm-up, aerobic exercises and cool-down. Variables including: anthropometrics measurements and exercise capacity (VO2max), and also coronary risk factors such as body mass index (BMI), waist-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood sugar (FBS), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), LDL-HDL ratio (LHR), body fat percent (BFP) were determined at the first and the last week of CR program in both groups. Results: Statistical analysis by independent t-test indicated that after program, there was a significant difference between 2 groups in VO2max, BMI, WHR, SBP, DBP, TC, TG, LDL, LHR (P<0.05), but there was no significant difference between the 2 groups in FBS, HDL, BFP. Conclusion: The CR program of the present study indicated a significant effect on exercise capacity and some coronary risk factors profile in CABG patients of 45-65 and can it be considered as a suitable program for CABG patients.
Behzad Moradi, Hasan Teymouri, Ali Porya, Mozhgan Khademi, Farzad Ebrahimzadeh,
Volume 19, Issue 2 (10-2017)
Abstract
Background: The incidence of atelectasis after coronary artery bypass graft surgery is highly recommended due to the impact of different levels of PEEP to prevent these complications. The aim of this study was to investigate the effects of different levels of PEEP after coronary artery bypass graft surgery.
Materials and Methods: This study was performed by clinical trial. The sample size in this study was 90 patients. Non-probability sampling was conducted in consecutive patients that using a stratified block randomized to intervention and control groups (each group n = 45). In the control group of patients after surgery, upon arrival in the intensive care unit until tracheal extubation rates PEEP of 5 cm H2O received Patients in the intervention group after entering the intensive care unit for 4 hours average PEEP of 10 cm H2O received. Six hours after tracheal extubation atelectasis of the final diagnosis of chest radiographs, oxygen saturation and body temperature were used. For statistical analysis, chi-square test and t-test used.
Results: The incidence of atelectasis in the intervention group, in 7 patients were about (15.6%) in the control group, and in 16 patients were about (35.6%) which was statistically significant difference (P= 0.03). The mean arterial oxygen saturation was more higher in the intervention group rather than the control group and the difference was statistically significant (P= 0.025).
Conclusion: This study shows that the use of PEEP levels of 10 cm H2O after coronary artery bypass graft surgery can reduce the incidence of postoperative atelectasis. So, it is recommended to use this method in order to reduce the incidence of atelectasis.
Farhad Fathipur, Leila Zarei, Rahim Mohammadi,
Volume 23, Issue 0 (11-2021)
Abstract
Background: The aim of this study was to perform a functional and histological study of the effect of coenzyme Q10 using allografts in a rat sciatic nerve repair model.
Materials and Methods: 45 male rats were randomly divided into three groups of 15. The first group received 10 μl of sterile normal saline buffer solution intraperitoneally for one week. Buffer was injected intraperitoneally to each rat. In the third group, the left sciatic nerve was removed and each rat received the sciatic nerve extracted from the second group and was injected intraperitoneally with the same volume of coenzyme Q10 at a dose of 200 mg / kg / day for one week. Rats underwent histological evaluation and histomorphometric studies and sciatic nerve function index at 4, 8 and 12 weeks postoperatively.
Results: The morphometric and functional indices of the sciatic nerve in the third group were significantly different from the second group (P <0.05). These indicators were improved in the third group.
Conclusion: The results of this study showed that topical injection of coenzyme Q10 in the inflammatory phase after rat sciatic nerve resection accelerated the process of nerve regeneration by reducing the process of secondary damage.
Mahshid Mehdizadeh, Hoda Kouhestani, Maria Tavakoli Ardakani, Elham Roshandel, Masoud Soleimani,
Volume 23, Issue 0 (11-2021)
Abstract
Although hematopoietic stem cell transplantation is a potential solution in the treatment of many blood malignancies and immune disorders, graft versus host disease (GVHD) has posed many challenges. Chronic (c)GVHD is one of the leading causes of death in acute GVHD survivors. Up to 70% of transplanted patients will experience cGVHD. Various studies have demonstrated the essential role of B cells in the development of cGVHD. These cells use various mechanisms in triggering cGVHD, including production of alloantibodies, activation of complement system, promoting antibody-dependent cell cytotoxicity, and cross-presentation of antigens and immune complexes to CD4+ T and CD8+ T cells. B cells can also interfere the peripheral tolerance of T cells. High level of alloreactive and autoreactive B cells as well as low level of regulatory B cells are observed in cGVHD patients, and are associated with the cGVHD severity. Therefore, B cell subsets should be considered in the transplantation procedure. B cell manipulation and targeting in allogeneic transplantation could be a promising approach to prevent and control cGVHD. In this article, we reviewed the roles of B cells in the pathophysiology of cGVHD.
Reza Mirfakhraie, Bentolhoda Kuhestani Dehaghi, Mahshid Mahdizadeh, Mohammad Hossein Kazemi, Elham Roshandel,
Volume 23, Issue 5 (1-2022)
Abstract
Background: Despite recent advances in hematopoietic stem cell transplantation (HSCT), graft-versus-host disease (GVHD) is still one of the most challenging post-transplant complications with a considerable mortality rate. Various strategies, including chemotherapy, depletion of T lymphocytes, monoclonal antibodies, corticosteroids, and other immunosuppressive drugs are used to reduce GVHD incidence, which usually increases the risk of cancer relapse and various infections in patients. The recently conducted studies have introduced oncolytic virotherapy as a promising solution to prevent GVHD and enhance the graft-versus-tumor effects. Oncolytic viruses are non-pathogenic viruses capable of selective lysis of cancer cells. These viruses can differentiate between allogeneic T lymphocytes and hematopoietic stem cells, and suppress allogeneic T cells. This review study aimed to discuss the mechanisms of oncolytic virotherapy in reducing the incidence of GVHD.
Ehsan Saboory, Mones Moloody, Azar Pad, Leila Zarei,
Volume 24, Issue 4 (3-2023)
Abstract
Background: Peripheral nerve injuries are among the serious health problems of today's societies. These injuries cause long-term disabilities that last until the end of life. This study aimed to histologically and functionally determine the effect of alpha-tocopherol using allografts in a rat sciatic nerve repair model.
Materials and Methods: In this experimental study, 45 male rats were divided into three groups (n=15 each). Group 1 was designated as the healthy group without nerve manipulation. In group 2, as the positive control group, the rats received 10 μl of sterile normal saline buffer solution intraperitoneally for one week. In the third group, designated as the treatment group (allografts, alpha-tocopherol), alpha-tocopherol was intraperitoneally injected with the same volume at a dose of 300 mg/kg/day for one week. Subsequently, the rats underwent histological evaluation postoperatively at the 4th, 8th, and 12th weeks following the operation. The collected data were entered into SPSS version 17 software. After evaluating the normality of the data by the Shapiro-Wilks test, the results were reported as mean ± standard deviation, and were analised by One Way ANOVA tests and Tukey,s post HOC test under significance level of 0.05.
Results: The results showed that the morphometric and functional indices of the sciatic nerve in the third group were significantly different from the second group (P<0.05). These indicators were improved in the third group.
Conclusion: Treatment with alpha-tocopherol and allografts resulted in significant differences with the control and allografts groups in terms of axon diameter, the number of nerves, and the thickness of the myelin sheath. These differences imply the beneficial effect of this drug on inflammatory cells in the spinal cord and brain.
Ahmad Tamjidipour, Niloofar Baharvandi, Asghar Rajabzadeh,
Volume 26, Issue 3 (10-2024)
Abstract
Background: The phrenic nerve is a sensory and motor nerve and is important from an anatomical and clinical point of view due to the innervation of the diaphragm muscle. The present report aimed to to describe the anatomical variation of a rare case related to the phrenic nerve and the internal thoracic artery.
Materials and Methods: During the routine autopsy of a 53-year-old man, it was found that the initial part of the internal thoracic artery was covered by a ring of the right phrenic nerve and then continued downward.
Results: Anatomical changes in the phrenic nerve and internal thoracic artery are always of special clinical importance, and if not considered in regional surgeries, they can lead to potentially life-threatening complications.
Conclusion: The investigation of this case showed that the phrenic nerve and the internal thoracic artery can show different positions relative to each other. It seems that since the first and second parts of the artery wall have elastic tissues, it can disrupt the innervation of the diaphragm muscle by affecting the phrenic nerve.
