Volume 15, Issue 3 (9-2013)
yafte 2013, 15(3): 5-14 |
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shahsavar F, Sabooteh T, Forutani S, Jafarzadeh M, asadifar B. Comparison of KIR/HLA genotypic analysis in the Lur and Iranian populatins. yafte 2013; 15 (3) :5-14
URL: http://yafte.lums.ac.ir/article-1-1319-en.html
URL: http://yafte.lums.ac.ir/article-1-1319-en.html
Abstract: (10838 Views)
Introduction: Killer-cell Immunoglobulin-like Receptors (KIR) are the members of inhibitory and activating receptors expressed chiefly by the natural killer cells (NK). KIR proteins operate as receptors detecting human leukocyte antigen class Ι molecules (HLA). KIRs and their class Ι HLA ligands contribute in the pathogenesis of many kinds of diseases. The aim of this study was to genotypic analysis of KIR/HLA in the Lur population for the first time.
Materials and Methods: In this study, 100 unrelated healthy Lur individuals were KIR and HLA ligand typed by polymerase chain reaction-sequence specific primers genotyping assay. Finally, the frequency of KIR and HLA ligand genes and genotypes, as well as KIR/HLA combinations in the Lur population was compared with the Iranian population.
Results: Twenty two KIR genotypes and all of the KIR genes were observed in the Lur population. The most prevalent non-framework genes were KIR2DL1 and KIR2DP1 with the frequency of 98% and KIR3DL1 and KIR2DS4 with the frequency of 96% in the Lur population. AA genotype with the frequency of 29% was the most frequent KIR genotype ever regarded in the Lur population. The number one genotype with the frequency of 35% was the most frequent genotype in the Lur population among HLA ligand genotypes. The most common inhibitory and activating KIR/HLA combinations were KIR2DL2/3+HLA-C1 with the frequency of 75% and KIR2DS2+HLA-C1 with the frequency of 47%, respectively.
Discussion and Conclusion: The results illustrate that the frequency of KIR genes and genotypes, HLA ligands and the KIR/HLA combinations has total similar features with the Iranian population, but it is still unique by increasing or decreasing of some frequencies in the Lur population.
Type of Study: Research |
Received: 2013/09/20 | Accepted: 2013/11/5 | Published: 2013/11/5
Received: 2013/09/20 | Accepted: 2013/11/5 | Published: 2013/11/5
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