Volume 18, Issue 1 (5-2016)                   yafte 2016, 18(1): 113-121 | Back to browse issues page

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Farahani M. The antiviral effect of three plant species of Iran on HSV-1 . yafte 2016; 18 (1) :113-121
URL: http://yafte.lums.ac.ir/article-1-2221-en.html
Islamic Azad University
Abstract:   (19098 Views)

Background : plants have had special position in human life and their medicinal application have been observed in manuscripts of many world scientists. Nowadays the treatment of HSV-1 infections with the available

 chemical drugs often leads to the problems due to viral resistance and virus latency duration, therefore there is a requirement for new anti-herpes drugs.In this research the antiviral effects of  Camellia sinesis, Echium amoenumL and Nerium oleander, with ethnomedical background on HSV-1 were studied.

Materials and Methods:The plants were extracted with decoction method to obtain aqueous extracts and after evaluating their cytotoxicity on Hep-2 cell lines by evaluating CPE, antiherpes effect of the plants extracts were determined by cytopathic effect inhibition assay.

Results: Nerium oleander extract had the  most toxicity (> 50 μg/ml) on cell line and Camellia sinesis showed the most inhibitory property on HSV-1 multiplication. Echium amoenumL had the lowest antiherpes effect. Camellia sinesis was inhibitor of virus multiplication completely at 50-1000 μg/ml and Echium amoenumL at concentrations >300 μg/ml.

Conclusion: Camellia sinesis and Echium amoenumL could inhibit well HSV-1 multiplication completely at concentrations nontoxic. Further researches are needed to find the effect mechanism of these drugs which may be used in the manufacture of new antiherpes drugs.

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Type of Study: Research |
Received: 2016/05/17 | Accepted: 2016/05/17 | Published: 2016/05/17

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