Volume 21, Issue 3 (11-2019)                   yafte 2019, 21(3): 144-152 | Back to browse issues page

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Mahmoudvand H, Mirzaei M, Khatami M, Mahmoudvand H, Kheirandish F, Niazi M, et al . In vitro and ex vivo effects of Quercus infectoria extract on hydatid cyst protoscolecs. yafte. 2019; 21 (3) :144-152
URL: http://yafte.lums.ac.ir/article-1-2870-en.html
Department of Surgery, Lorestan University of Medical Sciences, Khorramabad, Iran
Abstract:   (3092 Views)
Background: This study aims to evaluate the scolicidal effects of oak (Quercus infectoria) extract on hydatid cyst protoscoleces in vitro and ex vivo.
Materials and Methods: Following the collection of protoscoleces from sheep livers infected with fertile hydatid cysts from a slaughterhouse in Khorramabad, they were treated with various concentrations of oak extract (250-1000 µg/mL) for 5-40 min in vitro and ex vivo. Finally the mortality of protoscoleces was assessed by the eosin exclusion test (0.1% eosin staining).
Results: The mean of the mortality of protoscoleces was 100% after 5 min incubation with the concentration of 1000 mg/ml of oak extract. On the other hand, the mean of the mortality of protoscoleces after 10 incubation with the concentration of 500 mg/ml of oak extract was 100%. However, these results were not observed in the ex vivo analysis. That is, oak extract requires a longer length of time to display potent protoscolicidal effects.
Conclusion: The results of this investigation revealed that oak extract could have a significant scolicidal activity on hydatid cyst protoscoleces. However, further research, particularly in human and animal subjects, is required to reach this conclusion.
Keywords: Hydatidosis, Echinococcus granulosus, extract, hydatid sand, hcolicidal.
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Type of Study: Applicable | Subject: انگل شناسی
Received: 2019/06/5 | Accepted: 2019/12/29 | Published: 2020/04/3

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