Volume 22, Issue 4 (1-2021)                   yafte 2021, 22(4): 25-36 | Back to browse issues page

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Shahavand H, Hoseynpoor Delavar S, Behpoor N, Safikhani H, Azizi M. Effect of one course of aerobic exercise on the gene expression of angiopoietin-1 (ANGPT-1) and cardiac tissue oxidative status (TOS) in diabetic rats. yafte. 2021; 22 (4) :25-36
URL: http://yafte.lums.ac.ir/article-1-3027-en.html
Department of Physical Education and Sport Science, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
Abstract:   (1116 Views)
Background: Patients with diabetes mellitus are at high risk of antioxidants and in long-term vascular lesions. Therefore, the aim of the present study was to evaluate the effect of one course of aerobic exercise on the gene expression of angiopoietin-1 (ANGPT-1) and cardiac tissue oxidative status (TOS) in diabetic rats.
Materials and Methods: 30 male Wistar rats were divided into 3 groups (n= 10) diabetic training, diabetic control and healthy control groups. Animals in diabetic groups were diabetic by intraperitoneal injection of streptozotocin. The exercise program consisted of 6 weeks of treadmill training. 24 hours after the last training session to evaluate the effect of exercise, cardiac tissue samples were extracted to measure gene expression  of ANGPT-1 and total oxidative status. One-way ANOVA with statistical level (P<0.05) was used to compare the differences between groups.
Results: The results showed that gene expression of ANGPT-1 and TOS were significantly increased in the diabetic training group compared to the diabetic control group (P= 0.001) but only in the ANGPT-1 there were no significant differences (P= 0.001) between two groups of diabetic control and healthy control (P>0.05).
Conclusion: It seems that endurance training has a positive effect on the expression of ANGPT-1 gene and improves the overall antioxidant status of the heart tissue of diabetic rats and improve the diabetic heart.
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Type of Study: Research | Subject: فیزیولوژی حیوانی
Received: 2020/05/17 | Accepted: 2020/11/4 | Published: 2021/02/23

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