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Islamic Azad university
Abstract:   (115 Views)
Background:  Hypothyroidism among endocrine glands patient is the most common disease after diabetes. In hypothyroidism, the secretion of hormone that regulate the metabolism (of fats, Carbohydrates and protein) is reduced. the purpose of this study was to investigate the effect of hydro-alcolic  ginger extract  as the drug to increase the metabolism on the amount of glucose in normal and hypothyroidism rats.
Materials and methods:  In order to do this test, 60 male Wistar rats were divided into 6 groups: the control group did not receive any material. The controls received 0/1 mL of saline solution for 24 days. the experimental group 1 received 60 mg/kg of methimazole for 24 days. The experimental group 2 received  ginger hydroalcoholic extracts of 400 mg / kg, experimental group 3 and 4 received methizmol 60 mg / kg and simultaneously received ginger hydroalcoholic extract with doses of 200 mg / kg and 400 mg for a period of twenty four days, respectively. 48 hours after the first injection, anesthesia was done using ether and blood sample of their heart was collected. The amount of glucose was measured by autho analyzer machine. The dats collected was analyzed by SPSS and ANOVA.
 Results: There was a significant increase in the amount of glucose in the blood sample of experimental group (1) compared with control group. After using hydro-alcoholic ginger extract in group (3) and (4) a significant decrease was observed.
Conclusion: Based on these results, it can be predicted that, using ginger can decrease the amount of glucose in the blood of patients with hypothyroidism.
Type of Study: Applicable | Subject: فارماکولوژی
Received: 2021/04/12 | Accepted: 2021/08/22

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