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ABSTRACT
Background : Colorectal cancer is one of the most common gastrointestinal cancers in the world that has a high prevalence in middle-aged people. The aim of this study was to evaluate and compare changes in serum levels of CEA and CA19-9, as two important tumor markers, in the diagnosis of different stages of colorectal cancer.
Materials and Methods: This study was an experimental science study and a single subject design study in which 67 hospitalized patients with colorectal cancer were considered. At first, tissue samples and venous blood samples were collected from patients. Then, CEA and CA19-9 tumor markers were measured by enzyme-dependent fluorescence (ELFA) and cellular changes were studied by H&E staining.
Results: From 67 patients, 57.6% were male and 43.3% were female, of which 59.7% (40 patients) were over 61 years old. The most common sites of tissue involvement were the rectum and sigmoid. In the acute phase of the disease, the number of red blood cells (p= 0.0091) and the level of hemoglobin decreased (p=0.141), while the number of platelets remained unchanged (p=0.212). In addition, at first, lymphocyte and neutrophil counts increased and then decreased. The findings showed that there was a significant relationship between these two tumor markers and disease levels.
Conclusion: Our results showed that although these tumor markers are not suitable factors for the diagnosis of this cancer in the early stages, they can be used as two important markers to diagnose the progression of the disease..
Keywords: Colorectal Cancer, Tumor marker, CEA, CA-19-9
     
Type of Study: Research | Subject: علوم آزمایشگاهی
Received: 2021/04/24 | Accepted: 2021/07/19

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