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Yazdani N, Hossini S E, Edalatmanesh M A. Effect of Aloe vera ethanolic extract on biochemical parameters and histlogical changes of the kidney in rats fed with a high – fat diet. yafte 2021; 23 :86-98
URL: http://yafte.lums.ac.ir/article-1-3337-en.html

Abstract
Background and Objectives: A high-fat diet(HFD) can damage the kidneys. Aloe vera gel with fat reducing properties is used to treat kidney disorders. The aim of this study was to determine the effect of Aloe vera ethanolic extract on biochemical parameters and histological in the kidney tissue of rats fed with HFD.
Materials and methods:In this study , 40 adult male Wistar rats were purchased and randomly categorized in to the 5 groups animals, including two control groups ( control, control fed with a HFD and The experimental groups were divided into simultaneous recipient (H.F.D) and doses of 150, 300 and 600 mg / kg of aloe vera extract, respectively Prescriptions were performed for 60 days.finally after blood sampling, kidney tissue was dissected and histopathologically examined histopathologically and serum concentrations of BUN ,total protein , creatinine and albumin were measured. Data were analyzed using one way analysis of variance and Duncan post hoc test.
Results: Fed with a H.F.D increased the serum concenrations of BUN and creatinine and decreased serum albumin concentrations (P<0.05).The use of aloe vera extract in rats fed a high-fat diet improved renal tissue, significantly reduced BUN concentrations, and increased serum albumin and total protein concentrations.No significant effect was observed in the mean serum concentrations of creatinine in the groups receiving aloe vera Ethanolic extract.
Conclusion:  aloevera ethanolic extract  may reduced serum concentrations BUN, increased serum albumin , total protein in rats fed with a HFD. Also, aloevera extract improved the structure of kidney tissue.