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Papi S, Ahmadvand H, Sotoodehnejadnematalahi F, Yaghmaei P. Protective effect of indole-3-acetic acid on biochemical parameters of serum urea and creatinine in renal ischemia-reperfusion injury through antioxidant properties in a male rat model. yafte 2021; 23 :189-198
URL: http://yafte.lums.ac.ir/article-1-3349-en.html

Background: Renal ischemia-reperfusion can lead to acute renal failure. The use of antioxidants is a good way to reduce the damage caused by renal ischemia-reperfusion. Therefore, the aim of this study was to investigate the protective effect of indole-3-acetic acid on renal ischemia-reperfusion injury through its antioxidant properties in a rat model.
Materials and Methods: Forty male rats were treated for 2 weeks in four groups included (control group, ischemia-reperfusion control group, ischemia-reperfusion group with 40 mg/kg indole acetic acid treatment and ischemia-reperfusion group with 60 mg/kg indole acetic acid treatment). Then, the blood sample was taken from the heart. Serum urea and creatinine levels were measured using biochemical kits and superoxide dismutase enzyme levels were measured using photometric methods.
Results: The results showed that ischemia-reperfusion caused a significant increase in urea )P≤0/05) and creatinine) P≤0/05)  levels and a significant decrease in the level of superoxide dismutase in ischemia-reperfusion rats compared to the control group. However, indole acetic acid caused a significant decrease in serum urea) P≤0/05) and creatinine e)P≤0/05)  levels and a non-significant increase in superoxide dismutase enzyme compared to the ischemia-reperfusion control group )P>0/05).
Conclusion: The use of indol acetic acid was involved in reducing the renal biochemical parameters of urea and creatinine, which were increased due to ischemia-reperfusion injury, and caused the level of Super oxide dismutase enzyme to increase non-significant.