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Center of Physical Education, Isfahan University of Technology, Isfahan 84156-83111, Iran
Abstract:   (121 Views)
Background. The search to identify genetic differences affecting athletic performance has become a challenge recently. Iranian weightlifters and karate-kas are the champions of Olympics. Therefore, the aim of study was the comparison of ACE gene single nucleotide polymorphism (rs4646994) profile in Iranian elite karate-kas and weightlifters.
Materials and Methods. The subjects were included of elite weightlifters, karate-kas and non-athletes. By completing the demographic form and checking the health status and signing the written consent by the participants, 5 ml of saliva samples were collected from them. ACE genotypes were determined by PCR and electrophoresis on agarose gel. Data analysis was performed by ANOVA, chi-square and logistic regression. Significance level was considered 0.05.
Results: The results showed that the prevalence percent of D allele in weightlifters, karatekas and non-athletes were 58.3, 73.4 and 65.1, respectively. The results showed that the percent of ID genotype in elite weightlifting groups (56.7%) and non-athletes (46.5%) and DD genotype in elite karate-ka groups (61.7%) were significantly more common (P< 0 .05). Also the Comparison of genotype distribution showed a significant difference between karate-ka and weightlifter groups (χ2=7.471 , P = 0.024). In addition the results showed that none of the Ins / Del polymorphic genotypes of ACE gene had a significant relationship with the status of weightlifter or karate-ka (p> 0.05). 
Conclusion: In the study of ACE I / D gene, ID genotype was the most common in the weightlifting group and DD genotype was the most common in the karate group, which is probably a helpful result for those interested in sports talent to choose and participate in one of these two disciplines.
Type of Study: Research | Subject: علوم آزمایشگاهی
Received: 2022/04/9 | Accepted: 2022/05/28

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