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Islamic Azad University
Abstract:   (109 Views)
Background: Depression has caused many complications in human societies. Depression is one of the most common mental disorders and manifests itself as a global health problem in all cultures. On the other hand, saffron has been suggested as one of the effective plants in treating various types of depression.In the present study, the effect of the aqueous saffron extract on depression caused by chronic social defeat stress (CSDS) in rats was investigated.
Materials and Methods: Male Wistar intruder rats (220-230 g) were exposed in the cage of male Wistar resident rats (280-300 g) for ten consecutive days (20 min/day). Five min before exposure, the intruder rats received either saffron extract (1, 5, and 10 mg/kg) or saline (1 ml/kg). After the exposure, the animals’ weight, their desire for sucrose solution, and their locomotor activity were recorded.  Moreover, after exposure to stress in three stages; at the beginning of the experiments, one week after stress, and on the twelfth day (end of stress), blood samples were collected from the retro-orbital sinus of animals for evaluation of plasma corticosterone levels. Data were analyzed using SPSS software and Kolmogorov-Smirnov (KS) test and two-way repeated measures analysis-variance (ANOVA).
Results :Animals in the stress group showed severe weight loss (p<0.05), decreased desire to drink sucrose solution (p<0.05), decreased mobility (p<0.05), and increased plasma corticosterone level (p<0.05). Administration of aqueous saffron extract improved these symptoms in a dose-independent manner (p<0.01).
Conclusion:These results indicate that aqueous saffron extract has an important role in reducing depression in the animal model of chronic social defeat stress, which is applied by reducing corticosterone secretion in response to stress.
Key Words: Chronic Social Defeat Stress; Corticosterone; Depression; Saffron Water Extract. 
Type of Study: Research | Subject: فارماکولوژی
Received: 2022/04/30 | Accepted: 2022/07/1

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