Volume 24, Issue 2 (7-2022)                   yafte 2022, 24(2): 78-90 | Back to browse issues page

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Ghasemian Yadegari J, Khalili Fard Ardali J, Dehghan F, Haghighatian Z, Rashidipour M, Mohammadi H et al . Investigating the effect of Satureja Khusestanica essential oil on chlorpyrifos-induced spleen toxicity in male Wistar rats. yafte 2022; 24 (2) :78-90
URL: http://yafte.lums.ac.ir/article-1-3516-en.html
Department of Toxicology, Faculty of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran
Abstract:   (260 Views)
Background: Chlorpyrifos is a type of organophosphorus poison that, despite its widespread use, can lead to tissue damage, including spleen tissue. Khuzestani savory plant has antioxidant properties and is effective in reducing damage caused by oxidative stress. The aim of this study was to investigate the effect of Khuzestani savory plant essential oil on chlorpyrifos-induced spleen toxicity in male Wistar rats.
Materials and Methods: In this experimental research, 28 adult male rats weighing between 180-220 grams were selected and divided into 4 groups of 7. Were examined. Statistical comparison between the control group, Khuzestani essential oil 25 mg/kg, chlorpyrifos poison 0.01 mg/kg and Khuzestani essential oil 25 mg/kg + chlorpyrifos poison 0.01 mg/kg using SPSS 22 software and square test Chi was performed with Monte Carlo simulation under a significance level of 0.05.
Results: Chi-square test showed that there was a statistically significant difference between different groups in terms of the distribution of spleen tissue damage types (P=0.005); So, in the chlorpyrifos poison group, tissue damage such as macrophage and pigment accumulation and spleen white pulp analysis was observed, while no tissue damage was observed in the other groups.
Conclusion: Our study showed that the Khuzestan savory plant is effective in preventing tissue damage due to its antioxidant compounds such as carvacrol. Also, considering the negative effects of chlorpyrifos in the doses recommended by the World Health Organization, further investigations are necessary.
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Type of Study: Research |
Received: 2022/05/13 | Accepted: 2022/07/1 | Published: 2022/07/1

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