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 Introduction: Organophosphates are pesticides and inhibitors of the acetylcholinesterase enzyme.Chlorpyrifos and diazinon are two organophosphate toxins. Despite their widespread use, they can lead to oxidative stress.Therefore cause tissue damage, including splenic tissue. Satureja Khuzestanica plant has antioxidant properties and is effective in reducing damage caused by oxidative stress.
Materials and Methods: In this thesis, forty-two rats underwent ten-day treatment with toxins and essential oils and underwent surgery. Their spleens were removed for acquiring tissue slide and examined for pathology by hematoxylin and eosin staining. Then, a statistical comparison was performed between the control group and the groups receiving diazinon (0.0002 mg/kg) and chlorpyrifos (0.01 mg/kg) toxins. Also, a statistical comparison between the groups receiving toxins with Satureja Khuzestanica essential oil (25mg/kg) and the groups receiving toxins was performed.
Results: In this study, it was found that diazinon at this dose had no toxic effect on the spleen, and the simultaneous use of diazinon and Satureja Khuzestanica essential oil did not cause damage to the spleen. However, mice exposed to chlorpyrifos were injured, but no harm was seen with the simultaneous use of Satureja Khuzestanica essential oil with chlorpyrifos.
Conclusion: Satureja Khuzestanica plant is effective in preventing tissue damage due to antioxidant compounds such as carvacrol. Due to the negative effect of chlorpyrifos in the doses recommended by the World Health Organization, further investigation is necessary, and according to the results, the use of diazinon in agriculture is less dangerous than chlorpyrifos.
Type of Study: Research |
Received: 2022/05/13 | Accepted: 2022/07/1

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