Volume 13, Issue 3 (12-2011)
yafte 2011, 13(3): 64-74 |
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Toolabi P, Tavafi M, Ebrahimi S, Nasri S, Ahmadvand H. Protective effect of hydroalcohlic olive leaf extract on inhibition of Gentamicin-induced nephrotoxicity in rat. yafte 2011; 13 (3) :64-74
URL: http://yafte.lums.ac.ir/article-1-564-en.html
URL: http://yafte.lums.ac.ir/article-1-564-en.html
Faculty of Basic Sciences and Agriculture, Payame Noor University of Tehran, Tehran, Iran, Pooran.toolabi@yahoo.com
Abstract: (18203 Views)
Background : Administration of Gentamicin is restricted due to its nephrotoxicity. Many studies have demonstrated that free radicals induced Gentamicin- nephrotoxicity. Olive leaf contains some antioxidant biophenols such as Oleuropin. In this study for the first time the effect of hydroalcohlic olive leaf extract on Gentamicin-induced nephrotoxicity was investigated.
Materials and Methods: 35 male Sprague-Dowley rates were randomly divided into five groups. The first group served as a control and injected with the normal saline. Nephrotoxicity induced by Gentamicin (100 mg/kg) in experimental groups for 12 days. Three groups were treated with hydroalcohlic olive leaf extract (25, 50 and 100 mg/kg respectively). The rats were killed on the twelfth day.Plasma Malondialdehyde (MDA) and creatinine concentrations were measured. Kidney sections were prepared and stained with PAS method for histopathological studies.
Results: hydroalcohlic olive leaf extract at 25, 50 and 100 mg/kg/d significantly reduced gentamicin-induced tubular necrosis (p<0.05) and inhibited decreases of proximal tubule volume density (p<0.05). hydroalcohlic olive leaf extract at 50 and 100 mg/kg/d significantly reduced lymphocyte infiltration in comparison with Gentamicin administrated rats (p<0.05). Gentamicin increased level of MDA. Treatment with extract (100 mg/kg/d), significantly reduced level of MDA compared with other groups (p<0.05).Use of extract at 25, 50 and 100 mg/kg/d significantly inhibited increase of serum creatinine (p<0.001). Treatment with extract (50 mg/kg/d), significantly inhibited increase of serum urea (p<0.05).
Conclusion: Hydroaleohlic olive leaf extract can reduce Gentamicin-induced nephrotoxicity and this effect is probably depends on antioxidant properties of this extract.
Type of Study: Research |
Received: 2011/12/6 | Accepted: 2021/10/13 | Published: 2011/12/15
Received: 2011/12/6 | Accepted: 2021/10/13 | Published: 2011/12/15
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